NCT01541163

Brief Summary

Although cardio-embolic etiology of ischemic stroke (IS) is largely respected, there is still no clear recommendation for routine complex cardiological examination in all IS patients. Using complex cardiological examination the investigators expect:

  1. 1.more accurate detection of patients with concomitant heart disease (cardiac rhythm disorder, valve disorders, acute coronary syndrome, cardiac thrombus and myxoma, atrial and ventricle septum defects)
  2. 2.higher number of etiologically determinated IS, which is crucial for accurate secondary prevention.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Sep 2010

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2010

Completed
1.5 years until next milestone

First Submitted

Initial submission to the registry

February 23, 2012

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 29, 2012

Completed
6.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2018

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2018

Completed
Last Updated

November 1, 2017

Status Verified

October 1, 2017

Enrollment Period

7.8 years

First QC Date

February 23, 2012

Last Update Submit

October 31, 2017

Conditions

Brain IschemiaAcute StrokeHeart Diseases

Keywords

IschemiaBrain InfarctionAcute StrokeHeart DiseasesMyocardial Infarction

Outcome Measures

Primary Outcomes (1)

  • To assess the serum level profile of cardiac troponin T (cTnT) in acute ischemic stroke (AIS) patients and to evaluate factors associated with increased serum level of cTnT.

    Within 12 hours after ischemic stroke onset.

Secondary Outcomes (1)

  • Correlation between location and volume of brain infarction.

    At admission within 12 hours after stroke onset and after 24hours.

Study Arms (1)

Acute Ischemic Stroke

Patients with acute ischemic stroke admitted within 12 hours after onset.

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Consecutive ischemic stroke patients within 12 hours from stroke onset, who will be admitted at Comprehensive Stroke Center, Department of Neurology, University Hospital Olomouc from the October 2010 until December 2015.

You may qualify if:

  • Ischemic stroke admitted within 12 hours from stroke onset at stroke center

You may not qualify if:

  • none

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital Olomouc

Olomouc, 775 20, Czechia

RECRUITING

Related Publications (9)

  • Franc D, Sanak D, Kral M, Hutyra M, Taborsky M, Divisova P, Zapletalova J. Impact of prior oral anticoagulation on admission stroke severity in patients with atrial fibrillation. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2024 Jul 16. doi: 10.5507/bp.2024.024. Online ahead of print.

    PMID: 39023063DERIVED

  • Franc D, Sanak D, Divisova P, Lyskova L, Bartkova A, Zapletalova J, Kral M, Dornak T, Polidar P, Veverka T, Kanovsky P. Socioeconomic status and lifestyle in young ischaemic stroke patients: a possible relationship to stroke recovery and risk of recurrent event. Cent Eur J Public Health. 2021 Sep;29(3):223-229. doi: 10.21101/cejph.a6697.

    PMID: 34623123DERIVED

  • Divisova P, Sanak D, Vaclavik J, Kral M, Hutyra M, Zapletalova J, Bartkova A, Franc D, Dornak T, Veverka T, Taborsky M, Kanovsky P. Arterial Hypertension and Risk of Recurrent Event in Young Ischemic Stroke Patients. Can J Neurol Sci. 2021 May;48(3):358-364. doi: 10.1017/cjn.2020.200. Epub 2020 Sep 11.

    PMID: 32912364DERIVED

  • Divisova P, Sanak D, Kral M, Bartkova A, Hutyra M, Zapletalova J, Dornak T, Spacek M, Franc D, Polidar P, Veverka T, Kanovsky P. Young cryptogenic ischemic stroke: A descriptive analysis of clinical and laboratory characteristics, outcomes and stroke recurrence. J Stroke Cerebrovasc Dis. 2020 Sep;29(9):105046. doi: 10.1016/j.jstrokecerebrovasdis.2020.105046. Epub 2020 Jun 23.

    PMID: 32807456DERIVED

  • Sanak D, Divisova P, Hutyra M, Kral M, Bartkova A, Zapletalova J, Latal J, Dornak T, Hudec S, Franc D, Polidar P, Veverka T, Kanovsky P. Risk of recurrent ischemic stroke in young cryptogenic patients with embolic stroke of undetermined source. J Neurol Sci. 2020 Sep 15;416:116985. doi: 10.1016/j.jns.2020.116985. Epub 2020 Jun 13.

    PMID: 32563078DERIVED

  • Sanak D, Hutyra M, Kral M, Bartkova A, Zapletalova J, Fedorco M, Veverka T, Vindis D, Dornak T, Skala T, Skoloudik D, Taborsky M, Kanovsky P. Paroxysmal atrial fibrillation in young cryptogenic ischemic stroke: A 3-week ECG Holter monitoring study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Jun;159(2):283-7. doi: 10.5507/bp.2015.019. Epub 2015 Apr 24.

    PMID: 25916280DERIVED

  • Sanak D, Hutyra M, Kral M, Bartkova A, Zapletalova J, Fedorco M, Veverka T, Vindis D, Dornak T, Skala T, Skoloudik D, Taborsky M, Kanovsky P. Atrial fibrillation in young ischemic stroke patients: an underestimated cause? Eur Neurol. 2015;73(3-4):158-63. doi: 10.1159/000369793. Epub 2015 Jan 8.

    PMID: 25573455DERIVED

  • Kral M, Sanak D, Veverka T, Hutyra M, Vindis D, Bartkova A, Kuncarova A, Dornak T, Cechakova E, Herzig R, Langova K, Kanovsky P, Skoloudik D. Troponin T: Correlation with location and volume of acute brain infarction. Int J Cardiol. 2015 Feb 15;181:127-32. doi: 10.1016/j.ijcard.2014.12.027. Epub 2014 Dec 3.

    PMID: 25497535DERIVED

  • Kral M, Skoloudik D, Sanak D, Veverka T, Bartkova A, Dornak T, Hutyra M, Vindis D, Ulehlova J, Slavik L, Svabova M, Kubickova V, Herzig R, Kanovsky P. Assessment of relationship between acute ischemic stroke and heart disease--protocol of a prospective observational trial. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Sep;156(3):284-9. doi: 10.5507/bp.2012.094. Epub 2012 Oct 4.

    PMID: 23069890DERIVED

Related Links

MeSH Terms

Conditions

Brain IschemiaStrokeHeart DiseasesIschemiaBrain InfarctionMyocardial Infarction

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsInfarctionNecrosisMyocardial Ischemia

Study Officials

  • Michal Kral, MD

    University Hospital Olomouc

    STUDY DIRECTOR

Central Study Contacts

Michal Kral, MD

CONTACT

+420 604 171 594michal.kral@fnol.cz

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Study Director

Study Record Dates

First Submitted

February 23, 2012

First Posted

February 29, 2012

Study Start

September 1, 2010

Primary Completion

June 1, 2018

Study Completion

November 1, 2018

Last Updated

November 1, 2017

Record last verified: 2017-10

Locations

CZ(1)