Kochujang, a Fermented Soybean-based Red Pepper Paste, Decreases Visceral Fat and Improves Blood Lipid Profiles in Overweight Adults

NCT01532375 | Completed Phase 2 DMC

• 1 other identifier: CUH_2008_AT_4
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

With the epidemic of obesity and diabetes growing around the world, Kochujang (KCJ) may be potentially effective in preventing and treating obesity and cardiovascular risks if proven in humans. However, human trial still have not been reported with KCJ supplementation. In the present study, we investigated the hypothesis that KCJ supplementation can be decrease the body fat and improve blood lipid profiles in overweight adults.

Conditions

Overweight

Keywords

Kochujang,; visceral fat; population

Outcome Measures

Primary Outcomes (1)

• Visceral fat

  after 12 weeks of consumption

Secondary Outcomes (5)

• Body Mass Index

  after 12 weeks of consumption

• Subcutaneous fat

  after 12weeks

• Triglyceride

  after 12week of consumption

• Atherosclerosis index

  after 12weeks of consumption

• Apolipoprotein

  after 12weeks of consumption

Study Arms (2)

Kochujang(32g)

EXPERIMENTAL

Dietary Supplement: Kochujang

placebo(32g)

PLACEBO COMPARATOR

Dietary Supplement: placebo

Interventions

Kochujang DIETARY_SUPPLEMENT

Kochujang (32g/day) for 12weeks.

Kochujang(32g)

placebo DIETARY_SUPPLEMENT

placebo(32g/day) for 12weeks

placebo(32g)

Eligibility Criteria

• Age: 19 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI \>25kg/m2 and 2)Waist-Hip Ratio (WHR): WHR\> 0.90(male), WHR\>0.85(female)

You may not qualify if:

• lipid metabolic disorders
• \>10% changes in body weight in the past 3 months
• Cardiovascular disease such as arrhythmia, heart failure, myocardial infarction, and wearing pacemaker
• Allergy or hypersensitivity to any of the ingredients in the test products - History of reaction to any of the experimental products or of gastrointestinal diseases such as Crohn's disease or gastrointestinal surgery
• Participation in other clinical trials within the past 2 months
• Abnormal hepatic liver function, renal disease such as acute
• chronic renal failure, nephrotic syndrome
• Use of anti-psychosis drug therapy within 2 months
• Laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study
• History of alcohol or substance abuse
• Pregnancy or breastfeeding

Sponsors & Collaborators

• Chonbuk National University Hospital: lead

Related Publications (1)

• Cha YS, Kim SR, Yang JA, Back HI, Kim MG, Jung SJ, Song WO, Chae SW. Kochujang, fermented soybean-based red pepper paste, decreases visceral fat and improves blood lipid profiles in overweight adults. Nutr Metab (Lond). 2013 Feb 26;10(1):24. doi: 10.1186/1743-7075-10-24.

  PMID: 23442518 DERIVED

MeSH Terms

Conditions

Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Soo-Wan Chae, Ph.D, MD

  Chonbuk National University Hospital

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 10, 2012
• First Posted: February 14, 2012
• Study Start: October 1, 2009
• Primary Completion: March 1, 2010
• Study Completion: March 1, 2010
• Last Updated: February 14, 2012

Record last verified: 2012-02