NCT01472588

Brief Summary

Obesity is a significant and growing problem in the US that negatively impacts health and well-being of racial and ethnic minorities, people of low socioeconomic status, and persons living in rural communities and in the South. Obesity is a major concern in Arkansas, where the obesity rate for adults is higher than the rate for other adults in the nation. However effective weight loss programs are not typically available in these communities. Research has shown that the Diabetes Prevention Program (DPP) lifestyle intervention is effective in promoting weight loss in high risk individuals through changes in diet and physical activity that significantly reduce the chances of type 2 diabetes. Effective methods are desperately needed to translate the DPP to community settings, where obesity is a compelling public health burden. A major step in translating the DPP is to examine the efficacy of health professionals and community health workers (CHWs) in delivering the program in real-world settings. This is an important issue from the perspective of how evidence-based weight loss interventions can be provided to underserved, and resource constrained communities that typically may not have access to trained professionals for program delivery. The current project is a 5 year randomized controlled trial that examines DPP delivery and weight outcomes for individuals randomly assigned to either: (1) the DPP intervention delivered by CHWs or (2) the DPP intervention delivered by health professionals or (3) the Self Help condition. The study population consists of overweight adults (body mass index (BMI) \> 25) who reside in communities with a high proportion of African Americans. Primary outcome is change in body weight at 16 months. Cost effectiveness and lifestyle behaviors are also evaluated.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
277

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Sep 2007

Longer than P75 for phase_2

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2007

Completed
4.2 years until next milestone

First Submitted

Initial submission to the registry

October 25, 2011

Completed
22 days until next milestone

First Posted

Study publicly available on registry

November 16, 2011

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2014

Completed
Last Updated

October 23, 2023

Status Verified

September 1, 2014

Enrollment Period

6.3 years

First QC Date

October 25, 2011

Last Update Submit

October 19, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Weight Loss

    change in weight (% loss) from baseline to 16 months

    16 months

Secondary Outcomes (1)

  • Physical Activity

    16 months

Study Arms (3)

Community Health Coach

EXPERIMENTAL

DPP behavioral lifestyle intervention delivered by Community Health Coach (CHWs)

Behavioral: DPP lifestyle intervention-Community Health Coach (CHWs)

Public Health Coach

EXPERIMENTAL

DPP behavioral lifestyle intervention delivered by health professionals (PHCs)

Behavioral: DPP Lifestyle intervention--health professionals/(PHCs)

Self Help

OTHER

Booklet, Aim for a Healthy Weight (DHHS, NIH-NHLBI) provided.

Other: Self Help

Interventions

Lifestyle counseling. During a 16 month period, the behavioral weight loss program (n=24 sessions of the DPP lifestyle intervention) is delivered by CHWs in group format in community settings.

Also known as: DPP Lifestyle Balance Program
Community Health Coach

Lifestyle counseling. During a 16 month period, the behavioral weight loss program (n=24 sessions of the DPP lifestyle intervention) is delivered by PHCs in group format in community settings.

Also known as: DPP Lifestyle Balance Program
Public Health Coach

Public education/information booklet on weight management.

Also known as: Aim for a Healthy Weight (DHHS, NIH-NHLBI), --publically available education material.
Self Help

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Non-institutionalized men and women aged 18 and older
  • BMI \[weight (kg)/ height (m2)\] \> 25
  • Able to walk for exercise
  • Able to provide informed consent
  • Willing to accept random assignment

You may not qualify if:

  • Currently pregnant or nursing, or pregnant within previous 6 months
  • Recent heart attack or stroke (in past 6 months)
  • Congestive heart failure (NYHA Class 3-4)
  • History of bariatric surgery or weight loss in excess of 10% in past 6 months
  • Current use of weight loss medications
  • Another member of household enrolled in study
  • Presence of significant impairment that might interfere with participation, such as underlying disease likely to limit lifespan, infectious disease (e.g., HIV, tuberculosis), substantial cognitive impairment, renal dialysis, diagnosis of schizophrenia, psychosis or substance abuse, or other condition that might compromise participation or for which weight loss is not recommended
  • Plans to move from the area within the study period

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205, United States

Location

MeSH Terms

Conditions

Overweight

Interventions

CD5L protein, humanUnited States Dept. of Health and Human Services

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

United States Government AgenciesFederal GovernmentGovernmentOrganizationsHealth Care Economics and Organizations

Study Officials

  • Theresa E. Prewitt, DrPH

    University of Arkansas

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 25, 2011

First Posted

November 16, 2011

Study Start

September 1, 2007

Primary Completion

January 1, 2014

Study Completion

January 1, 2014

Last Updated

October 23, 2023

Record last verified: 2014-09

Locations