Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans

NCT01531738 | Completed Results DMC

• 1 other identifier: PRT
• Study Type: observational
• Target: 22
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste. The aim is to compare obese patients before and after bariatric surgery (gastric bypass and banding) to define the reward value of sweet, fatty and vegetable/fruit taste in obese individuals, and how this changes after surgery.

Conditions

Obesity

Keywords

Taste; bariatric surgery; food preferences; reward; progressive ratio task

Outcome Measures

Primary Outcomes (1)

• Breakpoints as Assessed by Change in the Number of Mouse Clicks in the Last Completed Ratio

  Patients were placed in front of a computer screen and a plate of 20 chocolate candies. The following prompt appeared on the screen: "You can earn food by clicking on the mouse button. Click as much or as little as you like. When you no longer want to continue, press the spacebar to stop the session."Upon completion of each ratio a message box appeared on the screen: "You have earned food. Enjoy your reward and after you have swallowed it completely you may click on OK to continue with the programme."After ingesting the reward, the patients pressed the OK button in the message box only if they wished to progress to the next ratio to obtain another chocolate candy. The starting ratio was 10 clicks with a geometric increment of 2 (i.e., 10, 20, 40, 80, and so on). When the effort of pressing the mouse button was greater than the rewarding value of the chocolate candy, patients pressed on the space bar to terminate the session. This indicated that the breakpoint was reached.

  2 weeks pre and 8-12 weeks post operatively for surgical patients or on two occasions 10-14 weeks apart for normal weight control group

Secondary Outcomes (2)

• Hunger

  2 weeks pre and 8-12 weeks post operatively for surgical patients or on two occasions 10-14 weeks apart for normal weight control group

• Body Mass Index

  2 weeks pre and 8-12 weeks post operatively for surgical patients or on two occasions 10-14 weeks apart for normal weight control group

Study Arms (2)

Control

Normal weight healthy volunteers

Bariatric Surgery

obese patients due to undergo gastric bypass or gastric banding

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with obesity attending a specialist obesity clinic and normal weight controls who are staff at Imperial College London

You may qualify if:

• BMI of 18-25 for normal weight volunteers
• BMI of \>30 for obese patients

You may not qualify if:

• Pregnancy
• breast feeding
• substance abuse
• consumption of more than 3 alcoholic units per day
• severe psychiatric illness
• lack of understanding of test instructions
• diabetes mellitus
• chronic medical conditions making a general anaesthetic unsafe
• allergy to stimulus ingredients
• active smoking

Sponsors & Collaborators

• Imperial College London: lead
• Medical Research Council: collaborator

Study Sites (1)

Imperial Weight Centre, Imperial College London

London, W6 8RF, United Kingdom

Location

Related Publications (1)

• Miras AD, Jackson RN, Jackson SN, Goldstone AP, Olbers T, Hackenberg T, Spector AC, le Roux CW. Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task. Am J Clin Nutr. 2012 Sep;96(3):467-73. doi: 10.3945/ajcn.112.036921. Epub 2012 Jul 25.

  PMID: 22836034 DERIVED

MeSH Terms

Conditions

Obesity; Food Preferences

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Feeding Behavior; Behavior

Results Point of Contact

• Title: Carel le Roux
• Organization: Imperial College

c.leroux@imperial.ac.uk

07970719453

Study Officials

• Carel W le Roux, MRCP PhD

  Imperial College London

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 6, 2012
• First Posted: February 13, 2012
• Study Start: July 1, 2010
• Primary Completion: January 1, 2012
• Study Completion: January 1, 2012
• Last Updated: November 16, 2020
• Results First Posted: October 22, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)