Effect of Two Physical Training Programs on Oxygen Uptake and Heart Rate On-kinetics in Patients COPD

NCT01529489 | Completed

• 1 other identifier: BVPS-123
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with chronic obstructive pulmonary disease (COPD) present slowed pulmonary oxygen uptake (VO2) and heart rate (HR) kinetics compared with age-matched controls. Patients with COPD present significant loss of body mass, decreased strength and endurance of respiratory muscles and lower limbs, leading reduced exercise capacity. This reduced exercise capacity can be marked by slowed kinetics of VO2 and HR at the onset of heavy-intensity exercise. Additionally, derangements in the diffusive and convective transport of oxygen to skeletal muscle mitocondria, and intramyocyte metabolic machinery, higher ventilation and disturbances in mechanics of breathing, hypoxemia, pulmonary hemodynamics, autonomic balance, and peripheral vasodilation, and accumulation of by-products that might be related to increased muscle fatigability could slow the response of systemic (central) and peripheral (microvascular) oxygen delivery to a point where the kinetics of VO2 might become limited by O2 availability and HR. Thus, the physical training programs of the lower limbs, in addition to presenting scientific evidence "A", are important components, resulting in the reversal of the manifestations of COPD, resulting in improvement in exercise capacity, well significantly speeded VO2 and HR kinetics in patients with COPD. However, it should be taken into account the choice of an appropriate program limitations and severity of disease. Assuming that COPD patients present slower VO2 and HR kinetics, the investigators hypothesized that the heavy-intense interval physical training in equipament elliptical would promote a greater increase in the functionality (functional performance) and speeded kinetics in the cycle ergometer and elliptical equipment constant-load intense exercises tests of COPD patients. In this context, the present study intends to evaluate and compare the effects of resistive plus aerobic physical training and interval physical training on oxygen consumption (VO2) and heart rate (HR) kinetics responses at the onset in cycle ergometer and elliptical equipment constant-load intense exercises tests in patients with COPD.

Conditions

Chronic Obstructive Pulmonary Disease; Healthy

Keywords

Chronic Obstructive Pulmonary Disease; Physical training; Oxygen uptake kinetic; Heart rate kinetic

Outcome Measures

Primary Outcomes (1)

• Effect of aerobic and resisted physical training and interval physical training on oxygen uptake and heart rate on-kinetics in patients with COPD.

  The kinetic analysis was measured before and after interval physical training and aerobic and resisted physical training by Cardiopulmonary Exercise Testing (CPT; Incremental symptom-limited exercise testing), Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical equipament. The on-transient (first 180 seconds) response of VO2 and HR was modeled according to a monoexponencial fit.

  baseline and 6 weeks

Secondary Outcomes (8)

• Change in oxygen consumption, minute ventilation, ventilatory limitation, pulmonary carbon dioxide output, metabolic rate.

  baseline and 6 weeks

• Change in oxygenation

  baseline and 6 weeks

• Change in heart rate and heart rate reserve

  baseline and 6 weeks

• Change in dyspnea and perceived discomfort in lower limbs

  baseline and 6 weeks

• Change in quality of life and Daily Life Activities

  baseline and 6 weeks

Study Arms (4)

Interval physical training Control group

ACTIVE COMPARATOR

Other: Interval physical training in elliptical equipament

Resisted/Aerobic physical training group

EXPERIMENTAL

Other: Resisted/Aerobic physical training

Aerobic/resisted physical training group

ACTIVE COMPARATOR

Other: Resisted/Aerobic physical training

Interval physical training group

EXPERIMENTAL

COPD, interval physical training, elliptical equipament, oxygen uptake kinetic, heart rate kinetic

Other: Interval physical training in elliptical equipament

Interventions

Resisted/Aerobic physical training OTHER

COPD, aerobic physical training in cicloergometer, resisted physical training in cicloergometer, oxygen uptake kinetic, heart rate kinetic.

Also known as: COPD,, aerobic physical training in cicloergometer,, resisted physical training in cicloergometer,, oxygen uptake kinetic,, heart rate kinetic.

Resisted/Aerobic physical training group

Interval physical training in elliptical equipament OTHER

Control group (healthy individuals), interval physical training, elliptical equipment, oxygen uptake kinetic, heart rate kinetic.

Also known as: Control group (healthy individuals),, interval physical training in elliptical equipment,, oxygen uptake kinetic,, heart rate kinetic.

Interval physical training Control group

Eligibility Criteria

• Age: 55 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Experimental Group:
• Patients with clinical and spyrometric diagnosis of COPD presenting FEV1/FVC \< 70% and FEV1 \< 80% predicted by pulmonary function observed and were classified as patients with moderate to very severe obstruction (GOLD, 2010).
• Clinically stable with no history infection or exacerbation of the respiratory symptoms or change in medication for two months preceding the study.
• Patients were non oxygen dependent, smokers or former smokers.
• No subject in the COPD group had ever participated in a pulmonary rehabilitation program (i.e., sedentary during the year preceding admission to the study).
• Adherence to the individually prescribed treatment regimen.
• Control Group:
• Pulmonary Function normal.
• Subjects in the control group were free of chronic pulmonary, cardiovascular, immune, and metabolic disease.
• Healthy controls who were sedentary during the year preceding admission to the study.

You may not qualify if:

• Patients with clinical diagnosis of COPD presenting FEV1/FVC ≥ 70% FEV1 ≥ 80% predicted (GOLD, 2010).
• Malignancy, orthopedic or neurological conditions affecting the ability to exercise, peripheral arterial disease, clinically apparent heart failure, and/or any renal, hepatic or inflammatory disease.
• Changed the type of medication during the study.
• Uncontrolled hypertension patients.
• Peripheral oxygen saturation below 90% at rest.

Sponsors & Collaborators

• Universidade Federal de Sao Carlos: lead

Study Sites (1)

Federal University of sao Carlos

São Carlos, São Paulo, 13565-905, Brazil

Location

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MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

Control Groups

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• Bruna V Pessoa, Ms

  Universidade Federal de Sao Carlos

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 2, 2012
• First Posted: February 8, 2012
• Study Start: January 1, 2008
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2011
• Last Updated: February 8, 2012

Record last verified: 2012-02

Locations

BR (1)