Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training

NCT01784432 | Completed DMC

• 1 other identifier: CAAE: 0150.0.135.000-10
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, low-level laser therapy has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations on global gene expression of muscle tissue influenced by exercise associated to low-level laser therapy.

Conditions

Healthy

Keywords

low-level laser therapy; muscle performance; strength training; gene expression; microarrays

Outcome Measures

Primary Outcomes (1)

• Global gene expression by microarray analysis

  12 weeks

Secondary Outcomes (2)

• Muscle performance in leg press device

  12 weeks

• Muscle performance in isokinetic dynamometer

  12 weeks

Other Outcomes (1)

• Immunohistochemical analysis

  12 weeks

Study Arms (2)

Low-level laser therapy and training

ACTIVE COMPARATOR

Effects of low-level laser therapy on muscle performance during physical strength training and gene expression of muscle tissue.

Device: Low-level laser therapy and training

Training without low-level laser therapy

ACTIVE COMPARATOR

Effects of physical strength training without low-level laser therapy on muscle performance and gene expression of muscle tissue

Other: Training

Interventions

Low-level laser therapy and training DEVICE

Also known as: Laser, Laser therapy, Low-level laser therapy

Low-level laser therapy and training

Training OTHER

Training without low-level laser therapy

Eligibility Criteria

• Age: 18 Years - 28 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy males aged between 18 and 28 years;
• body mass index (BMI) equal to or less than 26 kg/m2;
• moderated pattern of physical activity

You may not qualify if:

• previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),
• osseous or articular disorder in the lower limbs,
• cardiovascular system disorders,
• systemic disease, and
• taking prescription medicines or using dietary supplements such as muscle mass builders

Sponsors & Collaborators

• Universidade Federal de Sao Carlos: lead
• Fundação de Amparo à Pesquisa do Estado de São Paulo: collaborator
• Centro de Pequisas de Ótica e Fotônica: collaborator
• Faculty of Medicine of Ribeirão Preto (FMRP-USP): collaborator
• Fundação Hemocentro de Ribeirão Preto: collaborator

Study Sites (1)

Federal University of São Carlos

São Carlos, São Paulo, 13565-905, Brazil

Location

Related Publications (2)

• Ferraresi C, de Brito Oliveira T, de Oliveira Zafalon L, de Menezes Reiff RB, Baldissera V, de Andrade Perez SE, Matheucci Junior E, Parizotto NA. Effects of low level laser therapy (808 nm) on physical strength training in humans. Lasers Med Sci. 2011 May;26(3):349-58. doi: 10.1007/s10103-010-0855-0. Epub 2010 Nov 18.

  PMID: 21086010 BACKGROUND

• Vieira WH, Ferraresi C, Perez SE, Baldissera V, Parizotto NA. Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endurance training: a randomized controlled clinical trial. Lasers Med Sci. 2012 Mar;27(2):497-504. doi: 10.1007/s10103-011-0984-0. Epub 2011 Aug 26.

  PMID: 21870127 BACKGROUND

MeSH Terms

Interventions

Low-Level Light Therapy; Lasers; Laser Therapy

Intervention Hierarchy (Ancestors)

Therapeutics; Phototherapy; Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies; Ablation Techniques; Surgical Procedures, Operative

Study Officials

• Cleber Ferraresi, MSc

  Universidade Federal de Sao Carlos

  PRINCIPAL INVESTIGATOR

• Nivaldo A Parizotto, PhD

  Universidade Federal de Sao Carlos

  STUDY DIRECTOR

• Vanderlei S Bagnato, PhD

  University of Sao Paulo

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MSc

Study Record Dates

• First Submitted: September 15, 2012
• First Posted: February 5, 2013
• Study Start: January 1, 2011
• Primary Completion: January 1, 2012
• Study Completion: September 1, 2012
• Last Updated: February 5, 2013

Record last verified: 2013-02

Locations

BR (1)