Reconstruction of Proper Digital Nerve Defects in the Thumb Using a Pedicled Nerve Graft
1 other identifier
interventional
14
0 countries
N/A
Brief Summary
A proper digital nerve (PDN) defect in the thumb can produce partial or complete sensory loss which can result in functional disability. This article reports the treatment of the thumb PDN defect using a pedicled nerve graft harvested from the dorsal branch of the PDN. Fourteen patients with the thumb PDN defect underwent a new surgical procedure in which the pedicled nerve graft was used to bridge nerve defect. For comparison, the investigators also collected a consecutive series of 21 patients with thumb PDN defects treated using a nonvascularized sural nerve graft. This study was designed to evaluate the efficacy of pedicled nerve grafting for PDN defects in the thumb.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2005
Longer than P75 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2010
CompletedFirst Submitted
Initial submission to the registry
January 31, 2012
CompletedFirst Posted
Study publicly available on registry
February 8, 2012
CompletedFebruary 8, 2012
January 1, 2012
4.3 years
January 31, 2012
February 7, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
static 2-point discrimination (2PD) test
The test points were at the centers of the radial and ulnar portions of the thumb pulp and the donor sites separately. Each area was tested 3 times with a Dellon-Mackinnon discriminator. Two out of 3 correct answers were considered proof of perception before proceeding to another lower value.
22 months
Interventions
A pedicled nerve graft harvested from the dorsal branch of the PDN can be used for reconstruction of such defects. The graft is based on the second dorsal metacarpal artery.
Eligibility Criteria
You may qualify if:
- thumb PDN defects between the middle of the distal phalanx and the metacarpophalangeal joint;
- PDN defects of single or both sides;
- PDN defects 1-4 cm in length.
You may not qualify if:
- injury to the course of the pedicle or the donor sites;
- PDN defects less than 1 cm or longer than 4 cm;
- no Doppler sound at the location of the second dorsal metacarpal artery (SDMA).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- The Second Hospital of Tangshanlead
- Chinese PLA General Hospitalcollaborator
Related Publications (1)
Chen C, Tang P, Zhang X. Reconstruction of proper digital nerve defects in the thumb using a pedicle nerve graft. Plast Reconstr Surg. 2012 Nov;130(5):1089-1097. doi: 10.1097/PRS.0b013e318267d56b.
PMID: 23096609DERIVED
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 31, 2012
First Posted
February 8, 2012
Study Start
May 1, 2005
Primary Completion
September 1, 2009
Study Completion
May 1, 2010
Last Updated
February 8, 2012
Record last verified: 2012-01