Live Lung Donor Cross-sectional Cohort Study
1 other identifier
observational
192
1 country
2
Brief Summary
This study will gather information on the long-term effects of donating a lung lobe on living donors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2010
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2010
CompletedFirst Submitted
Initial submission to the registry
January 31, 2012
CompletedFirst Posted
Study publicly available on registry
February 2, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2012
CompletedMarch 27, 2017
March 1, 2017
2.1 years
January 31, 2012
March 23, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Spirometric lung function
Measured at time of scheduled spirometry testing
Secondary Outcomes (7)
Quality of life
Throughout study
Morbidity
Throughout study
Psychosocial status, including anxiety and depression symptoms
Throughout study
Satisfaction with live lung donation
Throughout study
Decision-making associated with live lung donation
Throughout study
- +2 more secondary outcomes
Study Arms (1)
Live lung donors
Live lung donors who participated in donation from 1993 through 2006
Eligibility Criteria
Live lung donors who participated in transplantation during 1993 through 2006
You may qualify if:
- Donated a lung at University of Southern California or Washington University between January 1, 1993 and December 31, 2006
You may not qualify if:
- For questionnaire testing: inability to comprehend and complete questionnaires (with assistance)
- For spirometry: self-reported pregnancy, inability to reproducibly perform, and contraindications
- For post-bronchodilator spirometry: allergy to albuterol
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University of Southern California
Los Angeles, California, 90033, United States
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Related Publications (1)
Yusen RD, Hong BA, Messersmith EE, Gillespie BW, Lopez BM, Brown KL, Odim J, Merion RM, Barr ML; RELIVE Study Group. Morbidity and mortality of live lung donation: results from the RELIVE study. Am J Transplant. 2014 Aug;14(8):1846-52. doi: 10.1111/ajt.12771.
PMID: 25039865RESULT
Related Links
Study Officials
- PRINCIPAL INVESTIGATOR
Mark Barr, MD
University of Southern California
- STUDY CHAIR
Roger Yusen, MD, MPH
Washington University School of Medicine
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 31, 2012
First Posted
February 2, 2012
Study Start
August 1, 2010
Primary Completion
September 1, 2012
Study Completion
October 1, 2012
Last Updated
March 27, 2017
Record last verified: 2017-03
Data Sharing
- IPD Sharing
- Will share
Participant level data and additional relevant materials are available to the public in the Immunology Database and Analysis Portal (ImmPort). ImmPort is a long-term archive of clinical and mechanistic data from DAIT-funded grants and contracts.