NCT01517802

Brief Summary

The purpose of this study is to collect follow-up safety data from participants in completed abiraterone acetate studies for a maximum duration of 9 years.

Trial Health

93
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
32

participants targeted

Target at below P25 for phase_3

Timeline
Completed

Started Mar 2012

Longer than P75 for phase_3

Geographic Reach
7 countries

22 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 23, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 25, 2012

Completed
2 months until next milestone

Study Start

First participant enrolled

March 28, 2012

Completed
9.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 22, 2021

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 22, 2021

Completed
1 year until next milestone

Results Posted

Study results publicly available

May 10, 2022

Completed
Last Updated

May 10, 2022

Status Verified

April 1, 2022

Enrollment Period

9.1 years

First QC Date

January 23, 2012

Results QC Date

April 20, 2022

Last Update Submit

April 20, 2022

Conditions

Keywords

Metastatic castration-resistant prostate cancerMetastatic breast cancerAbiraterone acetateLow-dose corticosteroid treatmentLong-term access

Outcome Measures

Primary Outcomes (1)

  • Number of Participants With Serious Adverse Events (SAEs)

    An SAE is defined as any untoward medical occurrence that results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, leads to a congenital anomaly/birth defect in the offspring of a participant, or is an important medical event.

    Up to 9 years

Study Arms (1)

Abiraterone acetate

EXPERIMENTAL

Patients will continue the same treatment regimen they were receiving during their participation in the previous abiraterone acetate clinical study.

Drug: Abiraterone acetateDrug: Prednisone

Interventions

Type=exact number, unit=mg, number=1000, form=tablet, route=oral, abiraterone acetate once daily

Abiraterone acetate

Type=exact number, unit=mg, number=5, form=tablet, route=oral, prednisone or prednisolone twice daily

Abiraterone acetate

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Currently participating in an abiraterone acetate clinical study considered complete and had received at least 3 months of treatment with abiraterone acetate tablets.

You may not qualify if:

  • Medical conditions that require hospitalization.
  • Any condition or situation which, in the opinion of the investigator, may put the patient at significant risk, may confound the study results, or may interfere significantly with the patient's participation in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (22)

Unknown Facility

Aurora, Colorado, United States

Location

Unknown Facility

Marrero, Louisiana, United States

Location

Unknown Facility

Boston, Massachusetts, United States

Location

Unknown Facility

Omaha, Nebraska, United States

Location

Unknown Facility

East Setauket, New York, United States

Location

Unknown Facility

New York, New York, United States

Location

Unknown Facility

Myrtle Beach, South Carolina, United States

Location

Unknown Facility

Chattanooga, Tennessee, United States

Location

Unknown Facility

Dallas, Texas, United States

Location

Unknown Facility

Houston, Texas, United States

Location

Unknown Facility

Kogarah, Australia

Location

Unknown Facility

Kurralta Park, Australia

Location

Unknown Facility

South Brisbane, Australia

Location

Unknown Facility

Subiaco, Australia

Location

Unknown Facility

Antwerp, Belgium

Location

Unknown Facility

Hamburg, Germany

Location

Unknown Facility

Barcelona, Spain

Location

Unknown Facility

Uppsala, Sweden

Location

Unknown Facility

Newcastle upon Tyne, United Kingdom

Location

Unknown Facility

Northwood, United Kingdom

Location

Unknown Facility

Sutton, United Kingdom

Location

Unknown Facility

Whitchurch, United Kingdom

Location

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Abiraterone AcetatePrednisone

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

AndrostenesAndrostanesSteroidsFused-Ring CompoundsPolycyclic CompoundsPregnadienediolsPregnadienesPregnanes

Limitations and Caveats

No site qualification or initiation visits conducted for previous studies on abiraterone acetate. No formal case report forms were developed nor clinical database was generated to capture data in this study. Due to disease condition, most of participants were lost to follow-up and hence data collected was not as planned. Data were recorded based on available source notes at participating sites and thereby into CIOMS. Studied population was very small hence it was difficult to generalize results.

Results Point of Contact

Title
DIRECTOR CLINICAL RESEARCH
Organization
Janssen Research & Development, LLC

Study Officials

  • Janssen Research & Development, LLC Clinical Trial

    Janssen Research & Development, LLC

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 23, 2012

First Posted

January 25, 2012

Study Start

March 28, 2012

Primary Completion

April 22, 2021

Study Completion

April 22, 2021

Last Updated

May 10, 2022

Results First Posted

May 10, 2022

Record last verified: 2022-04

Locations