Imaging Outcomes of Cognitive Behavioral Therapy (CBT) for Battered Women With Posttraumatic Stress Disorder

NCT01517672 | Completed

• 1 other identifier: STEIN VA MERIT
• Study Type: interventional
• Target: 41
• Locations: 1 country
• Sites: 1

Brief Summary

Identifying neural mechanisms of posttraumatic stress disorder (PTSD) treatment could help elucidate reasons for variable treatment response and identify novel treatment targets. Exposure-based therapies have been associated with decreased amygdala and increased cingulate cortex response during emotional processing. The current study examined whether cognitive therapy for PTSD in women reduces activation in insula and amygdala and enhances activation in prefrontal regions during emotional anticipation and pre-treatment prefrontal activation predicts treatment response.

Conditions

Posttraumatic Stress Disorder

Keywords

PTSD; domestic violence; intimate partner violence; functional MRI; neuroimaging

Outcome Measures

Primary Outcomes (1)

• Clinician-Administered PTSD Scale (CAPS)

  The CAPS is a widely used measure of PTSD severity. Intent was to administer 10 sessions of CBT over a period of 10-14 weeks. Primary outcome was CAPS at the end of CBT administration.

  After 10 sessions of cognitive behavioral therapy (CBT) (10-14 weeks)

Secondary Outcomes (1)

• CAPS 3 months post-treatment

  3 months post-treatment

Interventions

Cognitive Trauma Therapy for Battered Women (CTT-BW) BEHAVIORAL

10 individual sessions of this form of cognitive therapy, with a trained therapist.

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Female.
• Intimate partner violence (IPV) trauma defined as physical and/or sexual abuse committed by a romantic partner, occurring within five years of, but having ended at least one month prior to, enrollment in the study.
• Seeking treatment for posttraumatic stress disorder (PTSD) symptoms and meeting full or partial Diagnostic and Statistical Manual, 4th edition (DSM-IV) criteria for PTSD prior to treatment, verified through the Clinician-Administered PTSD Scale (CAPS).

You may not qualify if:

• Substance abuse in the past year
• History of \>2 years of alcohol abuse
• Use of psychotropic medications within 4 weeks prior to the study, bipolar disorder or schizophrenia, irremovable ferromagnetic bodily material, pregnancy, or claustrophobia.

Sponsors & Collaborators

• University of California, San Diego: lead
• San Diego Veterans Healthcare System: collaborator

Study Sites (1)

VA San Diego Healthcare System

San Diego, California, 92093, United States

Location

MeSH Terms

Conditions

Stress Disorders, Post-Traumatic

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Study Officials

• Murray B Stein, MD, MPH

  University of California, San Diego

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 16, 2012
• First Posted: January 25, 2012
• Study Start: January 1, 2008
• Primary Completion: December 1, 2010
• Study Completion: December 1, 2010
• Last Updated: January 25, 2012

Record last verified: 2012-01

Locations

US (1)