Brown Fat Activity and White Fat Accumulation
Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy
1 other identifier
observational
32
1 country
1
Brief Summary
White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2008
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2011
CompletedFirst Submitted
Initial submission to the registry
January 20, 2012
CompletedFirst Posted
Study publicly available on registry
January 25, 2012
CompletedJanuary 25, 2012
January 1, 2012
2.9 years
January 20, 2012
January 24, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up
Baseline and up to 1 year
Change from Baseline in Visceral Adipose Tissue Volume at Follow-up
Baseline and up to 1 year
Change from Baseline in Presence of Brown Adipose Tissue
Baseline and up to 1 year
Change from Baseline in Abdominal Musculature Volume
Baseline and up to 1 year
Secondary Outcomes (1)
Change from Baseline in Anthropometric Measures at Follow-up
Baseline and up to 1 year
Study Arms (1)
Malignant Disease with no visualized BAT
Children 18 years or younger who 1) had PET/CT scans with evidence of malignant disease but no metabolically active brown adipose tissue (BAT) at diagnosis and 2) were disease free within 1 year of diagnosis.
Eligibility Criteria
Pediatric patients with a history of malignancy such that they are required to undergo PET/CT exams.
You may qualify if:
- Patients had PET/CT scans with evidence of malignant disease
- Patients had no metabolically active BAT at diagnosis on their PET/CT scan
- Patients were disease free within 1 year of diagnosis
You may not qualify if:
- Patients had PET/CT scans with no evidence of malignant disease
- Patients with metabolically active BAT at diagnosis on their PET/CT scan
- Patients were not disease free within 1 year of diagnosis
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Children's Hospital Los Angeles
Los Angeles, California, 90027-6062, United States
Related Publications (6)
Hamilton G, Smith DL Jr, Bydder M, Nayak KS, Hu HH. MR properties of brown and white adipose tissues. J Magn Reson Imaging. 2011 Aug;34(2):468-73. doi: 10.1002/jmri.22623.
PMID: 21780237BACKGROUNDGilsanz V, Chung SA, Jackson H, Dorey FJ, Hu HH. Functional brown adipose tissue is related to muscle volume in children and adolescents. J Pediatr. 2011 May;158(5):722-6. doi: 10.1016/j.jpeds.2010.11.020. Epub 2010 Dec 18.
PMID: 21168855RESULTGilsanz V, Smith ML, Goodarzian F, Kim M, Wren TA, Hu HH. Changes in brown adipose tissue in boys and girls during childhood and puberty. J Pediatr. 2012 Apr;160(4):604-609.e1. doi: 10.1016/j.jpeds.2011.09.035. Epub 2011 Nov 1.
PMID: 22048045RESULTGilsanz V, Chung SA, Kaplowitz N. Differential effect of gender on hepatic fat. Pediatr Radiol. 2011 Sep;41(9):1146-53. doi: 10.1007/s00247-011-2021-7. Epub 2011 Mar 15.
PMID: 21404026RESULTHu HH, Chung SA, Nayak KS, Jackson HA, Gilsanz V. Differential computed tomographic attenuation of metabolically active and inactive adipose tissues: preliminary findings. J Comput Assist Tomogr. 2011 Jan-Feb;35(1):65-71. doi: 10.1097/RCT.0b013e3181fc2150.
PMID: 21245691RESULTChalfant JS, Smith ML, Hu HH, Dorey FJ, Goodarzian F, Fu CH, Gilsanz V. Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy. Am J Clin Nutr. 2012 May;95(5):1144-9. doi: 10.3945/ajcn.111.030650. Epub 2012 Mar 28.
PMID: 22456659DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Vicente Gilsanz, MD, PhD
Children's Hospital Los Angeles
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
January 20, 2012
First Posted
January 25, 2012
Study Start
October 1, 2008
Primary Completion
September 1, 2011
Study Completion
September 1, 2011
Last Updated
January 25, 2012
Record last verified: 2012-01