Changes in Cerebral Glucose Metabolism After Electroconvulsive Therapy (ECT)

NCT01514435 | Completed

• 1 other identifier: BRECT-2006-PET
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

There exist already a few studies that have measured changes of brain metabolism pre and post Electroconvulsive Therapy (ECT) by Positron emission tomography (PET) but these were all performed in a small number of patients and used different methodologies. It is therefore not surprising that these investigations provided inconsistent results, as reviewed previously {{23 Schmidt,E.Z. 2008}}. In patients with treatment-refractory major depressive episodes, the investigators here therefore probed (a) whether changes in cerebral glucose metabolism measured by PET occur after treatment with ECT and (b) whether these correlate with the clinical amelioration of symptoms. To pursue this goal, the investigators assessed clinical effects, neurocognitive function, and brain metabolism using 18F-Fluoro-deoxyglucose (18F-FDG) PET at baseline and at the end of treatment. Patients with a treatment refractory depression - defined as absent clinical improvement of depressive symptoms after at least two trials with antidepressants from different pharmacologic classes adequate in dose, duration of at least 6 weeks, and compliance {{30 Berlim,M.T. 2007}} - in whom ECT had been intended on clinical grounds were consecutively asked for participation in this study. Patients had to be between 18 and 80 years old and to be physically healthy.

Conditions

Major Depressive Disorder

Keywords

depression; FDG-PET; Electroconvulsive therapy; glucose metabolism

Outcome Measures

Primary Outcomes (1)

• Brain glucose metabolism measured by FDG-PET

  one year

Study Arms (1)

ECT verum group

EXPERIMENTAL

Patients with treatment refractory depression treated with ECT

Device: Electroconvulsive therapy; Device: 18-Fluoro-desoxy-glucose positron emission tomography

Interventions

Electroconvulsive therapy DEVICE

treatment for major depression

Also known as: no other names

ECT verum group

18-Fluoro-desoxy-glucose positron emission tomography DEVICE

intravenous injection of 18-FDG, after 30 min PET-Scan of the brain for aprox. 40 min. It´s a neuroimaging technique.

Also known as: no other names

ECT verum group

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• clinical indication for ECT
• treatment refractory depressive episode
• age 18-85 y

You may not qualify if:

• addiction as a first diagnosis
• dementia

Sponsors & Collaborators

• Medical University of Graz: lead

Study Sites (1)

Medical University Graz; Department for Psychiatry

Graz, Styria, 8036, Austria

Location

Related Publications (2)

• Berlim MT, Turecki G. Definition, assessment, and staging of treatment-resistant refractory major depression: a review of current concepts and methods. Can J Psychiatry. 2007 Jan;52(1):46-54. doi: 10.1177/070674370705200108.

  PMID: 17444078 BACKGROUND

• Schmidt EZ, Reininghaus B, Enzinger C, Ebner C, Hofmann P, Kapfhammer HP. Changes in brain metabolism after ECT-positron emission tomography in the assessment of changes in glucose metabolism subsequent to electroconvulsive therapy--lessons, limitations and future applications. J Affect Disord. 2008 Feb;106(1-2):203-8. doi: 10.1016/j.jad.2007.06.009. Epub 2007 Jul 26.

  PMID: 17662472 BACKGROUND

MeSH Terms

Conditions

Depressive Disorder, Major; Depression

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Behavioral Symptoms; Behavior

Study Officials

• Bernd Reininghaus

  Medical University of Graz

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 11, 2012
• First Posted: January 23, 2012
• Study Start: May 1, 2006
• Primary Completion: May 1, 2009
• Study Completion: July 1, 2011
• Last Updated: January 23, 2012

Record last verified: 2012-01

Locations

AU (1)