Brain-imaging and Adolescent Neuroscience Consortium

NCT01511679 | Withdrawn

• 1 other identifier: BANC RFA-AA-12-006
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 4

Brief Summary

This is a multi-site study of adolescents 12-21 years-of-age to evaluate the long and shorter-term effect of adolescent alcohol use on the developing brain.

Conditions

Alcohol Abuse

Keywords

Alcohol abuse

Study Arms (3)

Alcohol-naive adolescents

A general population longitudinal cohort of alcohol-naïve (or h/o minimal recent-onset drinking) adolescents in three specific age-groups: early (12-14 y/o), middle (15-17 y/o), and late (18-21 y/o).

Treatment sample

A sample of adolescents who have a \>1 year history of heavy drinking but have agreed to stop drinking as part of their treatment plan

High risk sample

High-risk adolescents who have a family history of alcohol-use disorder and other risk factors (symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), Conduct Disorder, or Mood Disorder)

Eligibility Criteria

• Age: 12 Years - 21 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Male and female adolescents 12-21 years-of-age presenting for care at one of the participating medical clinics

You may qualify if:

• able to read and understand English
• available for follow-up
• parental consent/adolescent assent for those 12-17 years
• consent for those 18-21 years

You may not qualify if:

• Weight \> 300 lbs
• braces or unremovable embedded metal
• claustrophobia or inability to lie still in MRI machine
• current or past 12-mos pregnancy (females)
• requires urgent medical/mental health care

Sponsors & Collaborators

• Boston Children's Hospital: lead
• Massachusetts General Hospital: collaborator
• Mclean Hospital: collaborator
• Massachusetts Institute of Technology: collaborator

Study Sites (4)

McLean Hospital

Belmont, Massachusetts, 02478, United States

Location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location

Boston University School of Medicine

Boston, Massachusetts, 02118, United States

Location

Massachusetts Institute of Technology

Cambridge, Massachusetts, 02139, United States

Location

Related Links

• Center for Adolescent Substance Abuse Research at Children's Hospital Boston

Biospecimen

Retention: SAMPLES WITH DNA

Saliva DNA samples for future analyses.

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• John R Knight, MD

  Boston Children's Hospital

  PRINCIPAL INVESTIGATOR

• Gordon J Harris, PhD

  Massachusetts General Hospital

  PRINCIPAL INVESTIGATOR

• Simon Warfield, PhD

  Boston Children's Hospital

  PRINCIPAL INVESTIGATOR

• Avram Holmes, PhD

  Harvard University

  PRINCIPAL INVESTIGATOR

• Scott Lukas, PhD

  Mclean Hospital

  PRINCIPAL INVESTIGATOR

• Marisa Silveri, PhD

  Mclean Hospital

  PRINCIPAL INVESTIGATOR

• Marlene Oscar Berman, PhD

  Boston University

  PRINCIPAL INVESTIGATOR

• John Gabrieli, PhD

  Massachusetts Institute of Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 13, 2012
• First Posted: January 19, 2012
• Study Start: September 1, 2012
• Primary Completion: March 1, 2017
• Study Completion: September 1, 2017
• Last Updated: January 3, 2013

Record last verified: 2013-01

Locations

US (4)