Chocolate's Effect on the Cerebral Vasculature
A Randomised Trial of Effect of Chocolate Upon Cerebrovascular Reactivity in Healthy Adult Volunteers
1 other identifier
observational
24
1 country
1
Brief Summary
The popularity of chocolate can largely be attributed to its mood elevating properties, research shows that it contains antioxidants that also provide physical health benefits. Dark chocolate, in particular, contains high levels of an antioxidant called epicatechin, which is known to cause changes in blood vessels by relaxing them and increasing blood flow. Little is know about the immediate effects of chocolate consumption, or the differences between milk and dark chocolate with regards to these effects. The project will investigate the effect of a single bar of dark or milk chocolate upon blood flow to the brain, using simple ultrasound tests.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Feb 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 6, 2012
CompletedFirst Posted
Study publicly available on registry
January 10, 2012
CompletedStudy Start
First participant enrolled
February 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2012
CompletedJuly 27, 2012
July 1, 2012
January 6, 2012
July 26, 2012
Conditions
Keywords
Study Arms (1)
100 g containing 70% or 34% cocoa
Healthy controls
Interventions
Eligibility Criteria
Healthy controls
You may qualify if:
- No regular medication including vitamins/antioxidants
- Able to provide informed consent
You may not qualify if:
- Inability to perform breath-hold test
- Any known cardiovascular disease, diabetes, throid disease, high blood pressure, hyperlipidaemia or pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- NHS Greater Glasgow and Clydelead
- University of Glasgowcollaborator
Study Sites (1)
Western Infirmary
Glasgow, G11 6NT, United Kingdom
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CROSSOVER
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Sponsor's representative
Study Record Dates
First Submitted
January 6, 2012
First Posted
January 10, 2012
Study Start
February 1, 2012
Study Completion
February 1, 2012
Last Updated
July 27, 2012
Record last verified: 2012-07