Proprioceptive Postural Control and Diaphragm Paresis

NCT01505556 | Withdrawn DMC

• 2 other identifiers: 2012_SBrumagne_DiaphParesis1.5.104.03, G.0674.09
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Increased risk of falling is reported in individuals with chronic obstructive pulmonary disease. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance. The aim of the study is to clarify whether proprioceptive postural control is impaired in individuals with diaphragm paresis.

Conditions

Proprioceptive Postural Control; Respiratory Disorders; Chronic Obstructive Pulmonary Disease

Outcome Measures

Primary Outcomes (1)

• Proprioceptive postural control

  Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control.

  1 year

Study Arms (2)

Diaphragm paresis

Healthy controls

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patients from the University Hospital Leuven - Respiratory Disvision

You may qualify if:

• Age: 18-70 years old
• Unilateral or bilateral diaphragm paresis following paresis of phrenic nerve
• Willingness to sign the informed consent
• Age: 18-70 years old
• Spirometry: FEV1/FVC ≥ 0.7 and FEV1 \> 80%
• Willingness to sign the informed consent

You may not qualify if:

• History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant
• One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder
• Respiratory disorder other than diaphragm paresis
• Recent diagnosis of cancer
• Significant cardiovascular comorbidity

Sponsors & Collaborators

• KU Leuven: lead
• Universitaire Ziekenhuizen KU Leuven: collaborator

Study Sites (1)

Katholieke Universiteit Leuven

Leuven, Vlaams-Brabant, 3000, Belgium

Location

Related Publications (1)

• Janssens L, Brumagne S, Polspoel K, Troosters T, McConnell A. The effect of inspiratory muscles fatigue on postural control in people with and without recurrent low back pain. Spine (Phila Pa 1976). 2010 May 1;35(10):1088-94. doi: 10.1097/BRS.0b013e3181bee5c3.

  PMID: 20393397 BACKGROUND

MeSH Terms

Conditions

Respiration Disorders; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Simon Brumagne, PhD

  KU Leuven

  PRINCIPAL INVESTIGATOR

• Thierry Troosters, PhD

  KU Leuven

  PRINCIPAL INVESTIGATOR

• Wim Janssens, MD, PhD

  KU Leuven

  PRINCIPAL INVESTIGATOR

• Marc Decramer, MD, PhD

  KU Leuven

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. dr. Simon Brumagne

Study Record Dates

• First Submitted: January 4, 2012
• First Posted: January 6, 2012
• Study Start: January 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: January 1, 2015
• Last Updated: February 8, 2019

Record last verified: 2019-02

Locations

BE (1)