Nottingham Osteoarthritis Biomarker Study 2011

NCT01495455 | Completed

• 1 other identifier: 11049
• Study Type: observational
• Target: 140
• Locations: 1 country
• Sites: 1

Brief Summary

Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population. The investigators still have a poor understanding of the nature of osteoarthritis and factors that influence its development and progression. Identification of biochemical markers that relate to cartilage loss, bony overgrowth and other features that occur with osteoarthritis will advance our understanding. Over the last 5 years analytical methods have developed to measure a range of different biomarkers. This pilot study will use these analytical methods to measure biomarker levels in joint fluid, urine and blood of 50 participants with Osteoarthritis (OA) and 50 healthy volunteers. This study will provide novel pilot data on the changes in the composition of the synovial fluid, urine and blood in patients with OA. Apart from being a key target site for OA, the knee is a suitable joint for study because of its accessibility to clinical assessment, joint aspiration and imaging.

Conditions

Osteoarthritis

Outcome Measures

Primary Outcomes (1)

• Difference in the levels of pro-inflammatory and anti-inflammatory lipids mediators between individuals with knee osteoarthritis and those with normal knees.

  within 6 months of recruitment of last participant

Study Arms (2)

Knee osteoarthritis

No knee pain/osteoarthritis

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

\- Secondary care clinics

You may qualify if:

• All participants:
• Be able to provide written informed consent
• Aged 30 and over
• Knee OA patients:
• Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at least one compartment of the knee
• Normal controls:
• No knee pain
• No clinical or radiographic changes of knee OA

Sponsors & Collaborators

• University of Nottingham: lead

Study Sites (1)

Academic Rheumatology, University of Nottingham

Nottingham, NG5 1PB, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITH DNA

Serum, urine and synovial fluid.

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Officials

• Michael Doherty, MA MB FRCP

  University of Nottingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2011
• First Posted: December 20, 2011
• Study Start: February 1, 2012
• Primary Completion: January 1, 2013
• Study Completion: January 1, 2013
• Last Updated: January 30, 2013

Record last verified: 2013-01

Locations

GB (1)