Influence of Oxidative Dysbalance on Secondary Osteoarthritis
Biomechanical Factors of Secondary Osteoarthritis: Oxidative and Nitrosative Stress as Predictive Factors of Joint Destruction
1 other identifier
observational
60
1 country
1
Brief Summary
The important role of mechanical joint stress for the insert and progress of osteoarthritis (OA) is supported by recent studies. The degeneration of joint cartilage is caused either by unphysiological load of a healthy joint or physiological load of a damaged joint. The exact mechanisms leading from increased weight bearing and overuse to cartilage degeneration are mostly unknown. The hypothesis of the study is that parameters of oxidative stress in the joint synovial space reflect damages possibly leading to OA. These parameters correlate with parameters of oxidative stress in the peripheral blood. Aim of the study is the identification of such non- invasive obtainable biomarkers which represent the degenerative and regenerative changes in joint.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2010
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2010
CompletedFirst Submitted
Initial submission to the registry
October 25, 2010
CompletedFirst Posted
Study publicly available on registry
October 26, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2013
CompletedJuly 26, 2011
July 1, 2011
2.1 years
October 25, 2010
July 25, 2011
Conditions
Keywords
Study Arms (3)
Acute knee pain
Patients with a history of knee pain \< 6 months. The radiologic and arthroscopic OA stadium is less or equal II°. n=20.
Chronic knee pain
Clinical manifestation of knee joint OA, radiological and arthroscopic III° or more. n=20
Control group
Patients coming for post- primary repair of the cruciate ligament, having no inflammation and no sign of OA. n=10
Eligibility Criteria
University clinic, patients, residents of Düsseldorf, Germany and surrounding cities
You may qualify if:
- Planned knee joint arthroscopy
- No history of trauma
You may not qualify if:
- Neoplasia
- Rheumatoid arthritis
- Intake of Steroids, cytostatic drugs,immunosuppression
- Pregnancy or lactation
- Addiction
- Participation in other clinical trials
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Orthopedic Department, Heinrich-Heine University Medical School
Düsseldorf, North Rhine-Westphalia, D40225, Germany
Biospecimen
Arthroscopical obtained wash- out preparations of synovial space Synovial biopsies Blood serum samples
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 25, 2010
First Posted
October 26, 2010
Study Start
October 1, 2010
Primary Completion
November 1, 2012
Study Completion
November 1, 2013
Last Updated
July 26, 2011
Record last verified: 2011-07