Markers of Coronary Artery Disease During Exercise Testing

NCT01495091 | Completed

• 1 other identifier: 2011/1938 (REK)
• Study Type: observational
• Target: 327
• Locations: 1 country
• Sites: 1

Brief Summary

The main purpose of this study is to examine whether changes in biomarkers during exercise are related to coronary artery disease demonstrated by coronary angiography or echocardiography.

Conditions

Coronary Artery Disease; Cardiovascular Disease

Keywords

coronary artery disease; cardiovascular disease; exercise stress testing; biomarkers; NT-pro-BNP

Outcome Measures

Primary Outcomes (1)

• Coronary artery disease demonstrated by coronary angiography

  baseline

Secondary Outcomes (1)

• Future cardiovascular morbidity and mortality

  Up to 29 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from patients with chest pain/discomfort referred for exercise stress testing at Oslo University Hospital, including patients with acute chest pain referred to the emergency department, and referrals to the outpatient clinic.

You may qualify if:

• Patients referred to Oslo University Hospital Ullevål with chest pain/discomfort of unknown etiology and and a clinical suspicion of coronary artery disease.
• Intermediate or high pre test probability of coronary artery disease.
• Able to give informed, written consent.

You may not qualify if:

• Not able to perform the exercise test.
• Evidence of acute coronary syndrome.
• Known coronary artery stenosis where exercise testing is contraindicated.
• The presence of known moderate to severe valvular heart disease.
• Known heart failure or obvious clinical signs of heart failure.
• Ongoing atrial fibrillation or atrial flutter.
• Complete or partial bundle branch block.
• Digitoxin therapy.
• Pacemaker.
• Renal insufficiency (S-creatinine \>150 micromol/L).
• Known pregnancy.

Sponsors & Collaborators

• Oslo University Hospital: lead
• University of Oslo: collaborator

Study Sites (1)

Oslo University Hospital

Oslo, 0407, Norway

Location

Related Publications (2)

• Hansen CH, Cwikiel J, Bratseth V, Arnesen H, Flaa A, Seljeflot I. Effect of Revascularization on Exercise-Induced Changes in Cardiac and Prothrombotic Biomarkers in Patients with Coronary Artery Disease. Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221094029. doi: 10.1177/10760296221094029.

  PMID: 35437054 DERIVED

• Cwikiel J, Seljeflot I, Berge E, Arnesen H, Wachtell K, Ulsaker H, Flaa A. Pro-coagulant activity during exercise testing in patients with coronary artery disease. Thromb J. 2017 Jan 19;15:3. doi: 10.1186/s12959-016-0127-8. eCollection 2017.

  PMID: 28115916 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, serum.

MeSH Terms

Conditions

Coronary Artery Disease; Cardiovascular Diseases

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Arnljot Flaa, MD PhD

  Oslo University Hospital

  STUDY CHAIR

• Ingebjørg Seljeflot, Professor PhD

  Oslo University Hospital and University of Oslo

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr

Study Record Dates

• First Submitted: December 9, 2011
• First Posted: December 19, 2011
• Study Start: December 1, 2011
• Primary Completion: October 1, 2017
• Study Completion: March 1, 2022
• Last Updated: September 22, 2022

Record last verified: 2022-09

Locations

NO (1)