NCT01492413

Brief Summary

This study was designed to test the impact of a 12-week online behavioral modification program for weight loss, with or without a fortified beverage. Subjects are randomized to four conditions: 1) Online Basic Lifestyle Counseling (OBLI); 2) Online Lifestyle Counseling (OLC); 3) OBLI plus a beverage (BEV); 4) OLC + BEV. The three hypotheses were: 1)after 12 weeks, individuals in the OLC condition would lose more weight than those in OBLI; 2) after 12 weeks, the OLC + BEV condition would lose more weight than the OLC condition; and 3) after 12 weeks, the OBLI + BEV condition would lose more weight than the OBLI condition.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
572

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Oct 2008

Longer than P75 for not_applicable

Geographic Reach
2 countries

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2008

Completed
3.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2011

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2011

Completed
12 days until next milestone

First Submitted

Initial submission to the registry

December 13, 2011

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 15, 2011

Completed
Last Updated

December 15, 2011

Status Verified

December 1, 2011

Enrollment Period

3.2 years

First QC Date

December 13, 2011

Last Update Submit

December 14, 2011

Conditions

Keywords

OverweightObesity

Outcome Measures

Primary Outcomes (1)

  • body weight

    Body weight is assessed at baseline, 6 and 12 weeks. Body weight is determined using a calibrated scale.

    12 weeks

Secondary Outcomes (1)

  • DEXA-determined fat mass

    12 weeks

Study Arms (4)

Online basic lifestyle counseling (OBLI)

EXPERIMENTAL

Subjects receive one online informational class.

Behavioral: online lifestyle counseling and a fortified diet beverage

Online lifestyle counseling (OLC)

EXPERIMENTAL

Subjects receive 12 weekly online classes with a focus on behavior modification for weight loss.

Behavioral: online lifestyle counseling and a fortified diet beverage

OBLI intervention plus a fortified diet beverage (BEV)

EXPERIMENTAL

Subjects receive online basic lifestyle information (OBLI) plus a fortified diet beverage.

Behavioral: online lifestyle counseling and a fortified diet beverage

OLC plus fortified diet beverage (BEV)

EXPERIMENTAL

Subjects receive OLC plus diet beverage (BEV).

Behavioral: online lifestyle counseling and a fortified diet beverage

Interventions

The fortified diet beverage contains green tea extract (total catechin 167 mg), soluble dextrin fiber (10 g), and caffeine (100 mg).

OBLI intervention plus a fortified diet beverage (BEV)OLC plus fortified diet beverage (BEV)Online basic lifestyle counseling (OBLI)Online lifestyle counseling (OLC)

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Body Mass Index (BMI) of 25 to 40;
  • age 18 to 65 years;
  • blood pressure less than 140 mmHg systolic and 90 mmHg diastolic;
  • caffeine intake 100-400 mg/d; and
  • ability to participate in physical activity for a minimum of 150 min/week.

You may not qualify if:

  • pregnancy, lactation or actively trying to become pregnant;
  • medical illnesses or medications that could affect body weight;
  • cigarette smokers;
  • weight loss of 10 or more pounds in the last 3 months;
  • fasting blood glucose greater than 126mg/dl;
  • participation in a clinical research study that would conflict with the purpose of the current trial; and
  • other factors that in the judgment of the principal investigator may interfere with study participation or the ability to follow the intervention protocol.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Temple University

Philadelphia, Pennsylvania, United States

Location

Behavioral Medicine Research Center

Houston, Texas, 77030, United States

Location

MRC Human Nutrition Research

Cambridge, United Kingdom

Location

MeSH Terms

Conditions

OverweightObesity

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • John P Foreyt, Ph.D.

    Baylor College of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, Department of Medicine

Study Record Dates

First Submitted

December 13, 2011

First Posted

December 15, 2011

Study Start

October 1, 2008

Primary Completion

December 1, 2011

Study Completion

December 1, 2011

Last Updated

December 15, 2011

Record last verified: 2011-12

Locations