NCT01488916|Unknown
Vitamin D Inadequacy on Postprandial Glucose in Type 2 Diabetes Mellitus
Impacts of Vitamin D Inadequacy on Postprandial Glucose Excursion in Patients With Type 2 Diabetes
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Impacts of Vitamin D Inadequacy on Postprandial Glucose Excursion in Patients With Type 2 Diabetes
Sponsor study identifier
observational
45
1 country
1
Study Start
August 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Vitamin D deficiency is associated with an unfavorable metabolic profile in several observational studies. However, the influences of vitamin D concentrations on postprandial glucose in type 2 diabetes (DM) are less studied. The purposes of the study are to study the effects of vitamin D inadequacy on postprandial glucose excursion and metabolic responses in patients with type 2 DM. This is a cross-sectional study. About 150-180 patients will be screened for serum levels of 25(OH)D. A total of 45 eligible patients will be grouped into three groups by different vitamin D status: vitamin D deficiency, vitamin D insufficiency, and the controls. The patients will receive a mixed meal test for postprandial glucose excursion and metabolic responses. The investigators will use statistical methods to assess the differences in post-challenge glucose and metabolic response among the three groups of patients. The investigators hope the study can explore the relationship between vitamin D and glucose excursion in patients with type 2 DM.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 2011
Date type not reportedThis date has not been verified as actual or estimated.
December 6, 2011
Actual (reported)December 8, 2011
Actual (reported)July 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
incremental areas under the curves of plasma glucose after meal challenge
Within 20 days of the screening visit, the eligible participants will receive a 3-h mixed meal test for postprandial glucose excursion.
20 days
insulin sensitivity and β-cell function indexes from the meal test
20 days
Meal-related glycemic excursion indexes (∆G, ∆T, BR)from the meal test
20 days
patients with serum vitamin D levels of the lower tertile
patients with serum vitamin D levels of the middle tertile
patients with serum vitamin D levels of the upper tertile
In the present study, we propose to screen patients with type 2 DM for vatamin D inadequacy. Those with different vitamin D status will be invited to participate in a mixed meal test.
Taipei Veterans General Hospital
Taipei, 112, Taiwan
Serum samples after meal challenge
Chii-Min Hwu, MD
Taipei Veterans General Hospital, Taiwan
First Submitted
December 6, 2011
First Posted
December 8, 2011
Study Start
August 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
July 2012
The Effect of Whole Almonds on Biomarkers of Cardiovascular Disease in Chinese Patients With Type 2 Diabetes
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-401)
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
December 14, 2011
Record last verified: 2011-12
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