NCT01488162

Brief Summary

This multi-center, prospective, observational study will describe the management of relapsing or refractory chronic lymphocytic leukemia (CLL) patients. Data will be collected for 2 years.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
327

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2011

Longer than P75 for all trials

Geographic Reach
1 country

84 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 4, 2011

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

November 4, 2011

Completed
1 month until next milestone

First Posted

Study publicly available on registry

December 8, 2011

Completed
4.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 24, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 24, 2016

Completed
Last Updated

March 22, 2017

Status Verified

March 1, 2017

Enrollment Period

5.6 years

First QC Date

November 4, 2011

Last Update Submit

March 21, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Chemotherapy regimens associated with MabThera/Rituxan in management of relapse/refractory CLL: Percentage of patients receiving purine analogues/bendamustine/alkylating agents/other chemotherapy

    2 years

Secondary Outcomes (9)

  • Overall response rate

    2 years

  • Complete response rate

    2 years

  • Progression-free survival

    2 years

  • Time to next treatment

    2 years

  • Overall survival

    2 years

  • +4 more secondary outcomes

Study Arms (1)

Cohort

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Adult patients with relapsing or refractory chronic lymphocytic leukemia (CLL)

You may qualify if:

  • Adult patients, \>/=18 years of age
  • Diagnosis of relapsed or refractory chronic lymphocytic leukemia (CLL) with first or second relapse
  • Previous treatment with MabThera/Rituxan
  • MabThera/Rituxan treatment planned for current relapse

You may not qualify if:

  • Richter syndrome
  • Life expectancy \<6 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (84)

Unknown Facility

Aix-en-Provence, 13616, France

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Unknown Facility

Aix-en-Provence, 13617, France

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Unknown Facility

Albi, 81030, France

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Unknown Facility

Angers, 49933, France

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Unknown Facility

Antibes, 06600, France

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Argenteuil, 95107, France

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Arras, 62022, France

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Avignon, 84902, France

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Unknown Facility

Bayonne, 64109, France

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Unknown Facility

Béziers, 34525, France

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Unknown Facility

Béziers, 34535, France

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Blois, 41016, France

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Bobigny, 93009, France

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Bordeaux, 33030, France

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Bordeaux, 33077, France

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Boulogne, 62321, France

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Bourg-en-Bresse, 01012, France

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Brest, 29609, France

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Caen, 14033, France

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Caen, 14076, France

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Carcassonne, 11890, France

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Castelnau Lez, 34170, France

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Chalon-sur-Saône, 71321, France

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Chambéry, 73011, France

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Clermont-Ferrand, 63003, France

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Clermont-Ferrand, 63050, France

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Colmar, 68024, France

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Compiègne, 60321, France

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Corbeil-Essonnes, 91000, France

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Creil, 60109, France

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Fréjus, 83608, France

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Grenoble, 38000, France

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La Source, 45100, France

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La Tronche, 38700, France

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Le Mans, 72037, France

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Libourne, 33505, France

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Lyon, 69338, France

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Marseille, 13005, France

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Marseille, 13291, France

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Mâcon, 71018, France

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Melun, 77011, France

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Metz, 57038, France

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Metz, 57045, France

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Metz-Tessy, 74370, France

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Montauban, 82013, France

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Unknown Facility

Montpellier, 34295, France

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Mulhouse, 68070, France

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Unknown Facility

Nantes, 44093, France

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Unknown Facility

Nantes, 44202, France

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Nice, 06189, France

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Unknown Facility

Nice, 06202, France

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Unknown Facility

Nîmes, 30029, France

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Unknown Facility

Paris, 75181, France

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Unknown Facility

Paris, 75475, France

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Paris, 75571, France

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Paris, 75651, France

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Paris, 75679, France

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Perpignan, 66012, France

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Unknown Facility

Perpignan, 66046, France

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Pessac, 33604, France

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Pierre-Bénite, 69495, France

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Poitiers, 86021, France

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Pontoise, 95300, France

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Reims, 51092, France

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Rennes, 35000, France

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Unknown Facility

Rennes, 35033, France

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Roubaix, 59056, France

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Unknown Facility

Rouen, 76038, France

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Unknown Facility

Saint Prient En Jarez, 42271, France

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Unknown Facility

Saint-Brieuc, 22027, France

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Unknown Facility

Saint-Germain-en-Laye, 78105, France

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Unknown Facility

Saint-Herblain, 44805, France

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Unknown Facility

Saint-Quentin, 02321, France

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Unknown Facility

Salon-de-Provence, 13658, France

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Unknown Facility

Salouël, 80480, France

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Unknown Facility

Strasbourg, 67091, France

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Unknown Facility

Strasbourg, 67098, France

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Unknown Facility

Toulon, 83041, France

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Unknown Facility

Toulon, 83056, France

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Unknown Facility

Toulouse, 31059, France

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Unknown Facility

Tours, 37044, France

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Unknown Facility

Troyes, 10003, France

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Unknown Facility

Valence, 26953, France

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Unknown Facility

Villejuif, 94804, France

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MeSH Terms

Conditions

Leukemia, Lymphocytic, Chronic, B-Cell

Condition Hierarchy (Ancestors)

Leukemia, B-CellLeukemia, LymphoidLeukemiaNeoplasms by Histologic TypeNeoplasmsHematologic DiseasesHemic and Lymphatic DiseasesLymphoproliferative DisordersLymphatic DiseasesImmunoproliferative DisordersImmune System DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 4, 2011

First Posted

December 8, 2011

Study Start

April 4, 2011

Primary Completion

October 24, 2016

Study Completion

October 24, 2016

Last Updated

March 22, 2017

Record last verified: 2017-03

Locations