Study to Investigate the Safety, Pharmacokinetics, and Immunogenicity of Subcutaneous MCAF5352A in Healthy Volunteers

NCT01480310 | Completed Phase 1

• 1 other identifier: GA27909
• Study Type: interventional
• Target: 23
• Locations: 1 country
• Sites: 1

Brief Summary

This is a Phase Ia, randomized, double-blind, placebo-controlled, single ascending dose (SAD) study in male and female healthy volunteers, aged 18-55 years, enrolled at a single study site in Canada.

Conditions

Healthy Volunteer

Outcome Measures

Primary Outcomes (1)

• Incidence of adverse events

  up to approximately 100 days

Secondary Outcomes (4)

• Pharmacokinetic: maximum serum concentration (Cmax)

  up to approximately 100 days

• Pharmacokinetic: time to maximum serum concentration (tmax)

  up to approximately 100 days

• Pharmacokinetic: apparent clearance (CL/F)

  up to approximately 100 days

• Pharmacokinetic: Terminal half-life (t½)

  up to approximately 100 days

Study Arms (2)

A

EXPERIMENTAL

Drug: MCAF5352A

B

EXPERIMENTAL

Drug: Placebo

Interventions

MCAF5352A DRUG

may receive up to 3 subcutaneous doses of MCAF5352A

A

Placebo DRUG

may receive up to 3 subcutaneous doses of placebo

B

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Total body weight between 45 and 110 kg
• Vital signs within the following ranges: oral body temperature of 35°C to 37.5°C, systolic blood pressure of 90 to 140 mmHg, diastolic blood pressure of 50 to 90 mmHg, and pulse rate of 45 to 100 bpm
• Laboratory test parameters within normal reference ranges of the safety laboratory
• Female subjects: Willing to use two effective methods of contraception from screening to a minimum of 4 months after the last dose of study drug. Reliable forms of contraception include oral hormonal contraceptives, patch hormonal contraceptives, vaginal ring, intrauterine device, physical double-barrier methods, surgical hysterectomy, or vasectomy by male partner.

You may not qualify if:

• Pregnant or lactating women
• Administration of a live, attenuated vaccine within 30 days before Day 1 or anticipation that such a live attenuated vaccine will be required within 100 days of Day 1
• Subjects may receive influenza vaccination only during influenza season (approximately October to March). Subjects must not receive live attenuated influenza vaccine within 30 days prior to Day 1 or at any time during the study.
• Any major illness within 30 days prior to Day 1
• Clinically significant illness requiring treatment within 14 days prior to Day 1
• History of clinically significant ECG abnormalities or a known family history of cardiac conduction system disease
• Positive test results indicating current or past infection with human immunodeficiency virus (HIV-1 or 2), hepatitis B virus (hepatitis B surface antigen \[HBsAg\], hepatitis B core antibody \[anti-HBc\]), or hepatitis C virus (HCV)
• Positive screening test for latent mycobacterial infection within the 2 months preceding Day 1 without evidence of a completed course of anti-tubercular therapy or previous BCG vaccination
• History of significant chronic or recurrent infections
• History of clinically significant drug allergy and/or a known hypersensitivity to protein therapeutics or formulation components or a related drug
• History of alcohol or drug abuse within 12 months prior to Day 1, or evidence of such abuse as indicated by the specific screening laboratory tests results, or alcohol consumption of more than 14 units of alcohol per week
• Positive breathalyzer for alcohol or urine screen results for drugs of abuse, or prescription medications
• Subjects who have previously received the study drug
• Participation in a clinical trial within 4 weeks before Day 1 or use of any experimental or biologic therapy within the 12 weeks prior to Day 1 or within 5 half-lives of the product, whichever is greater
• Use of prescription drugs within 14 days prior to Day 1 or during the study, except for hormonal contraceptives or hormone replacement therapy

Sponsors & Collaborators

• Genentech, Inc.: lead

Study Sites (1)

Unknown Facility

Québec, Quebec, G1P 0A2, Canada

Location

Study Officials

• Clinical Trials

  Genentech, Inc.

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 23, 2011
• First Posted: November 28, 2011
• Study Start: December 1, 2011
• Primary Completion: June 1, 2012
• Study Completion: June 1, 2012
• Last Updated: November 2, 2016

Record last verified: 2016-11

Locations

CA (1)