French Biological Observatory on Lung Cancer in Never Smokers
BioCAST
1 other identifier
observational
422
1 country
82
Brief Summary
Lung cancer in non-smokers (LCINS) is an increasing public health problem. The BioCAST (IFCT-1002) study, promoted by Intergroupe Francophone de Cancérologie Thoracique (IFCT), focuses on this entity. It is a national, multicentric, prospective epidemiological study. Main objective is to describe the clinical and molecular epidemiology of LCINS in a large French cohort composed by cases newly diagnosed in participating centres (around to 1000 patients expected). The clinical component of the study is based on collecting data directly from the patient through a standardized questionnaire during a telephone interview with a health professional. The biologic component includes a blood sample collection. A large genomic-wide association study and an epigenetic study are also planned. BioCAST hopes to provide concrete answers to clinicians and patients questions about this new and frequent entity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2011
82 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2011
CompletedFirst Submitted
Initial submission to the registry
November 2, 2011
CompletedFirst Posted
Study publicly available on registry
November 7, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2013
CompletedMay 24, 2023
May 1, 2023
1.2 years
November 2, 2011
May 22, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Prevalence of EGFR mutations in never smokers with newly diagnosed non-small-cell lung cancer (NSCLC)
November 2011 to January 2013
Study Arms (1)
LCINS
Never smokers with newly diagnosed lung cancer
Eligibility Criteria
Never smokers with newly diagnosed lung cancer
You may qualify if:
- never smokers (i.e. who has smoked less than 100 cigarettes per lifetime)
- at least 18 years of age
- newly diagnosed lung cancer
- patient having access to a telephone
- french-speaking patient or patient who could be easily helped in his mother tongue during a phone interview
- signed informed consent
You may not qualify if:
- smokers
- chemotherapy already initiated at enrollment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (82)
Centre Hospitalier du Pays d'Aix
Aix-en-Provence, France
CHD Castelluccio
Ajaccio, France
Clinique Claude Bernard
Albi, France
CHU d'Angers
Angers, France
CHI Annemasse-Bonneville
Annemasse, France
CH Annonay
Annonay, France
Hôpital Privé d'Antony
Antony, France
CHIC
Aulnay-sous-Bois, France
CH de la Côte Basque
Bayonne, France
CHU Besançon
Besançon, France
Hôpital Ambroise Paré - Pneumologie
Boulogne, France
Hôpital Fleyriat
Bourg-en-Bresse, France
CH Jacques-Cœur - Pneumologie
Bourges, France
CH Pierre Oudot
Bourgoin, France
HCL Hôpital Louis Pradel
Bron, France
Centre François Baclesse
Caen, France
CHU Côte de Nâcre
Caen, France
CH Cahors
Cahors, France
CH de Cannes
Cannes, France
CH Chambery
Chambéry, France
CH de Chartres Hôpital Louis Pasteur
Chartres, France
CH de Chauny
Chauny, France
Centre Médical Nicolas de Pontoux
Châlon-sur-Saône, France
CH de Châlons-en-Champagne
Châlons-en-Champagne, France
Hôpital de Cholet - Pneumologie
Cholet, France
HIA Percy - Pneumologie
Clamart, France
Hôpitral Gabriel Montpied - Pneumologie
Clermont-Ferrand, France
Hôpital Pasteur
Colmar, France
CH Compiègne - Pneumologie
Compiègne, France
CHI Créteil
Créteil, France
CH de Dax
Dax, France
Cabinet privé
Dijon, France
Centre d'Oncologie du Parc
Dijon, France
Centre Georges François Leclerc
Dijon, France
CHU Hôpital du Bocage
Dijon, France
CHRU Grenoble
Grenoble, France
CH Région Saint-Omer
Helfaut, France
CH Lagny-sur-Marne
Lagny-sur-Marne, France
CH de Versailles
Le Chesnay, France
CH du Mans
Le Mans, France
Centre Oscar Lambret
Lille, France
Hôpital Calmette
Lille, France
CH de Longjumeau
Longjumeau, France
CH Lyon Sud - Pneumologie
Lyon, France
CH Saint Joseph Saint Luc
Lyon, France
Clinique Mutualiste Eugène André
Lyon, France
HIA Desgenettes
Lyon, France
Hôpital de la Croix Rousse
Lyon, France
Hôpital Ambroise Paré
Marseille, France
Hôpital Nord - Oncologie Multidisciplinaire & Innovations Thérapeutiques
Marseille, France
Polyclinique du Parc
Maubeuge, France
CH de Macon
Mâcon, France
CHR Metz Thionville
Metz, France
CH de Mont-De-Marsan
Mont-de-Marsan, France
CH Montélimar
Montélimar, France
CH de Mulhouse
Mulhouse, France
CHU Nancy
Nancy, France
Hôpital Laënnec - CHU de Nantes
Nantes, France
CH Nevers
Nevers, France
Centre Antoine Lacassagne
Nice, France
CHR d'Orléans La Source
Orléans, France
GH Paris Saint-Joseph
Paris, France
Hôpital Bichat - Claude - Bernard
Paris, France
Hôpital Saint Antoine
Paris, France
Hôpital Tenon
Paris, France
CH de Rambouillet
Rambouillet, France
Institut Jean Godinot
Reims, France
CHU Charles Nicolle
Rouen, France
CH de Saint-Brieuc
Saint-Brieuc, France
Institut de Cancérologie de la Loire
Saint-Priest-en-Jarez, France
CHU Strasbourg
Strasbourg, France
Hôpital Foch
Suresnes, France
Hôpitaux du Léman - Pneumologie et Maladies Infectieuses
Thonon-les-Bains, France
Hôpital Font-Pré - Pneumologie
Toulon, France
Clinique Pasteur
Toulouse, France
Clinique Saint Jean du Languedoc
Toulouse, France
Hôpital Larrey - Pneumologie
Toulouse, France
CHU Tours - Pneumologie
Tours, France
CH Valence
Valence, France
CHI de la Haute-Saône - Pneumologie
Vesoul, France
Clinique Mutualiste Les Portes du Sud
Vénissieux, France
CH de Villefranche - Pneumologie
Villefranche, France
Related Publications (6)
Couraud S, Debieuvre D, Moreau L, Dumont P, Margery J, Quoix E, Duvert B, Cellerin L, Baize N, Taviot B, Coudurier M, Cadranel J, Missy P, Morin F, Mornex JF, Zalcman G, Souquet PJ; BioCAST/IFCT-1002 study investigators. No impact of passive smoke on the somatic profile of lung cancers in never-smokers. Eur Respir J. 2015 May;45(5):1415-25. doi: 10.1183/09031936.00097314. Epub 2015 Mar 5.
PMID: 25745045RESULTCouraud S, Souquet PJ, Paris C, Do P, Doubre H, Pichon E, Dixmier A, Monnet I, Etienne-Mastroianni B, Vincent M, Tredaniel J, Perrichon M, Foucher P, Coudert B, Moro-Sibilot D, Dansin E, Labonne S, Missy P, Morin F, Blanche H, Zalcman G; French Cooperative Intergroup IFCT. BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers. Eur Respir J. 2015 May;45(5):1403-14. doi: 10.1183/09031936.00097214. Epub 2015 Feb 5.
PMID: 25657019RESULTCouraud S, Vaca-Paniagua F, Villar S, Oliver J, Schuster T, Blanche H, Girard N, Tredaniel J, Guilleminault L, Gervais R, Prim N, Vincent M, Margery J, Larive S, Foucher P, Duvert B, Vallee M, Le Calvez-Kelm F, McKay J, Missy P, Morin F, Zalcman G, Olivier M, Souquet PJ; BioCAST/IFCT-1002 investigators. Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers: a proof-of-concept study from BioCAST/IFCT-1002. Clin Cancer Res. 2014 Sep 1;20(17):4613-24. doi: 10.1158/1078-0432.CCR-13-3063. Epub 2014 Jul 10.
PMID: 25013125RESULTCouraud S, Labonne S, Missy P, Morin F, Tran Q, Deroy A, Milleron B, Blanche H, Zalcman G, Souquet PJ; les membres du Groupe de travail << non-fumeurs de l'IFCT >>. [Lung cancer in never smokers: a French national cohort (BioCAST/IFCT-1002)]. Rev Mal Respir. 2013 Sep;30(7):576-83. doi: 10.1016/j.rmr.2013.03.006. Epub 2013 May 18. French.
PMID: 24034464RESULTFontaine-Delaruelle C, Mazieres J, Cadranel J, Mastroianni B, Dubos-Arvis C, Dumont P, Monnet I, Pichon E, Locatelli-Sanchez M, Dixmier A, Coudert B, Fraboulet S, Foucher P, Dansin E, Baize N, Vincent M, Missy P, Morin F, Moro-Sibilot D, Couraud S; IFCT10-02 BioCAST investigators. Somatic profile in lung cancers is associated to reproductive factors in never-smokers women: Results from the IFCT-1002 BioCAST study. Respir Med Res. 2020 Mar;77:58-66. doi: 10.1016/j.resmer.2020.01.003. Epub 2020 Jan 31.
PMID: 32416585RESULTParis C, Do P, Mastroianni B, Dixmier A, Dumont P, Pichon E, Chouaid C, Coudert B, Foucher P, Fraboulet S, Locatelli-Sanchez M, Baize N, Dansin E, Moreau L, Vincent M, Missy P, Morin F, Moro-Sibilot D, Couraud S; BioCAST/IFCT-1002 study investigators; to the BioCAST/IFCT- 1002 study. Association between lung cancer somatic mutations and occupational exposure in never-smokers. Eur Respir J. 2017 Oct 26;50(4):1700716. doi: 10.1183/13993003.00716-2017. Print 2017 Oct.
PMID: 29074543RESULT
Related Links
Biospecimen
whole blood, serum, plama, white cells
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sebastien COURAUD, MD
Hospices Civils de Lyon, CH Lyon Sud, FRANCE
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 2, 2011
First Posted
November 7, 2011
Study Start
November 1, 2011
Primary Completion
January 1, 2013
Study Completion
January 1, 2013
Last Updated
May 24, 2023
Record last verified: 2023-05