NCT01460264

Brief Summary

This is an observational study aiming to identify and validate biomarkers (including imaging and clinical descriptors) for chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD) and lung cancer.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10,000

participants targeted

Target at P75+ for all trials

Timeline
7mo left

Started Oct 2013

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress96%
Oct 2013Dec 2026

First Submitted

Initial submission to the registry

October 25, 2011

Completed
1 day until next milestone

First Posted

Study publicly available on registry

October 26, 2011

Completed
2 years until next milestone

Study Start

First participant enrolled

October 16, 2013

Completed
13.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

August 29, 2025

Status Verified

August 1, 2025

Enrollment Period

13.1 years

First QC Date

October 25, 2011

Last Update Submit

August 22, 2025

Conditions

Chronic Obstructive Pulmonary DiseaseCardiovascular DiseasesLung Cancer

Keywords

Prospective Cohort StudyRespiratory Function TestsComputed TomographyElectrocardiographyPeripheral Arterial Disease

Study Arms (2)

exposed

current daily smokers 100 cigarettes or more during lifetime

unexposed

current non-smokers

Eligibility Criteria

Age45 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Community sample,residents in Skåne county Sweden.

You may qualify if:

  • years

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Skåne University Hospital

Lund, 221 85, Sweden

Location

Related Publications (1)

  • Gerhardsson de Verdier M. The big three concept: a way to tackle the health care crisis? Proc Am Thorac Soc. 2008 Dec 1;5(8):800-5. doi: 10.1513/pats.200806-058TH.

    PMID: 19017732BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

whole blood, serum

MeSH Terms

Conditions

Pulmonary Disease, Chronic ObstructiveCardiovascular DiseasesLung NeoplasmsPeripheral Arterial Disease

Condition Hierarchy (Ancestors)

Lung Diseases, ObstructiveLung DiseasesRespiratory Tract DiseasesChronic DiseaseDisease AttributesPathologic ProcessesPathological Conditions, Signs and SymptomsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsAtherosclerosisArteriosclerosisArterial Occlusive DiseasesVascular DiseasesPeripheral Vascular Diseases

Study Officials

  • Louise Hagman Bennet, MD, PhD

    Skane University Hospital

    STUDY CHAIR

  • David Erlinge, MD, PhD

    Skane University Hospital

    PRINCIPAL INVESTIGATOR

  • Claes-Göran Löfdahl, MD, PhD

    Skane University Hospital

    PRINCIPAL INVESTIGATOR

  • Maria Planck, MD, PhD

    Skane University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 25, 2011

First Posted

October 26, 2011

Study Start

October 16, 2013

Primary Completion (Estimated)

December 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

August 29, 2025

Record last verified: 2025-08

Locations

SE(1)