Is COPD a Risk Factor for Cardiovascular Disease?

NCT02162095 | Completed

• 1 other identifier: SNCTP000000995
• Study Type: observational
• Target: 162
• Locations: 1 country
• Sites: 1

Brief Summary

Patients with chronic obstructive pulmonary disease suffer from significant cardiovascular morbidity and mortality. This study wants to determine whether chronic obstructive pulmonary disease might be a risk factor for coronary atherosclerosis and other cardiac markers independent of conventional cardiovascular risk factors. The study is designed as a retrospective matched case-control study with follow-up via telephone interview.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

Chronic obstructive pulmonary disease; Coronary artery disease; Coronary calcium score

Outcome Measures

Primary Outcomes (1)

• Coronary calcium score in cardiac computed tomography

  Retrospective assessment of SPECT-CT imaging data at the University Hospital Zurich.

  Up to one month

Secondary Outcomes (2)

• Left ventricular ejection fraction in single-photon emission computed tomography

  Up to one month

• Major adverse cardiovascular events

  Up to three months

Study Arms (2)

Chronic obstructive pulmonary disease

Approximately 100 participants with documented chronic obstructive pulmonary disease (post-bronchodilator Forced expiratory volume in 1 second (FEV1)/Forced vital capacity (FVC) \< 0.7).

Control

Approximately 100 participants with exclusion of chronic obstructive pulmonary disease (post-bronchodilator Forced expiratory volume in 1 second (FEV1)/Forced vital capacity (FVC) \> 0.7).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with a history of smoking underdoing SPECT-CT imaging due to preoperative assessmentat the University Hospital Zurich between 01.01.2007 and 31.07.2013.

You may qualify if:

• SPECT-CT imaging due to preoperative assessment between 01.01.2007 and 31.07.2013.
• Coronary artery calcium score and left ventricular ejection fraction data available.
• History of smoking (smoker or ex-smoker).
• COPD group: Documented chronic obstructive pulmonary disease (post-bronchodilator FEV1/FVC \< 0.7).

You may not qualify if:

• Known coronary artery disease or coronary symptoms (angina pectoris) at the time of the SPECT-CT investigation.
• Known congenital or structural heart disease.
• Previous heart transplantation.

Sponsors & Collaborators

• University of Zurich: lead
• University Hospital, Zürich: collaborator

Study Sites (1)

University Hospital Zurich, Pulmonary Division

Zurich, Canton of Zurich, 8091, Switzerland

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Malcolm Kohler, MD, Prof

  University of Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 6, 2014
• First Posted: June 12, 2014
• Study Start: June 1, 2014
• Primary Completion: December 1, 2014
• Study Completion: December 1, 2014
• Last Updated: June 3, 2015

Record last verified: 2015-06

Locations

CH (1)