Study of Psychological Defense Mechanisms Used by Liver Transplant Patients

NCT01458756 | Completed

• 2 other identifiers: 2006_0623DGS 2006/0393
• Study Type: observational
• Target: 81
• Locations: 1 country
• Sites: 1

Brief Summary

Organ transplantation has a special place in the medical field. It symbolizes a medicine whose limits always seem to be repelled. Because transplantation is unusual, it places people in front of outstanding issues which he has to cope with his personality and history. Factors involved in the psychology of patient presenting with graft are past and present psychic functioning, object relations, experience of transplantation itself and quality of social environment. Before or after graft defense mechanisms can be so intense that they can make the patient unable to overcome the graft. Yet as a pathological mechanism that denial was considered beneficial provided it is short. The aim of this study is to evaluate on psychopathological influence of psychological defense mechanisms used by liver transplant patients on their somatic psychological and social outcome.

Conditions

Liver Diseases

Keywords

liver transplant patients; hepatic transplantation

Outcome Measures

Primary Outcomes (1)

• change in Bond Defense Style Questionnaire 88

  Change in psychological defense mechanisms measured by the Defense Style Questionnaire 88, prior and after liver transplantation

  baseline and 6 months and 1 year and 5 years

Secondary Outcomes (5)

• personality disorders evaluation by SCID II personality scale

  baseline and 6 months and 1 year and 5 years

• Minimal International Neuropsychiatric Interview MINI results

  6 months and 1 year and 5 years

• Alcohol Use Disorders Identification Test AUDIT score

  baseline and 6 months and 1 year and 5 years

• Change in mental health level by General Health Questionnaire GHQ 28

  baseline and 6 months and 1 year and 5 years

• social evolution

  baseline and 6 months and 1 year and 5 years

Study Arms (1)

liver transplant patients

Population of adult patients awaiting liver transplant, status on the waiting list in the transplant center of University Hospital of Lille.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients awaiting liver transplantation and registered on the waiting list in the transplant center of University Hospital of Lille

You may qualify if:

• adult patients between 18 and 65 years old
• liver disease requiring a liver transplantation
• registered on the waiting transplant list in the University Hospital of Lille

You may not qualify if:

• fulminant hepatitis
• mental incapacity

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

University Hospital, Lille

Lille, 59037, France

Location

MeSH Terms

Conditions

Liver Diseases

Condition Hierarchy (Ancestors)

Digestive System Diseases

Study Officials

• Olivier COTTENCIN

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 24, 2011
• First Posted: October 25, 2011
• Study Start: December 1, 2006
• Primary Completion: October 1, 2016
• Study Completion: October 1, 2016
• Last Updated: October 25, 2016

Record last verified: 2016-10

Locations

FR (1)