NCT01444560|CompletedDMC
miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi
The miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi
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The miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi
Sponsor study identifier
observational
21
1 country
1
Study Start
December 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2011
Actual (reported)Study Completion
September 2011
Actual (reported)MicroRNAs (miRNAs) are very small endogenous RNA molecules about 22-25 nucleotides in length, capable of post-transcriptional gene regulation. miRNAs bind to their target messenger RNAs (mRNAs), leading to cleavage or suppression of target mRNA translation based on the degree of complementarity. miRNAs have recently been shown to play pivotal roles in diverse developmental and cellular processes and linked to a variety of skin diseases and cancers. In the present study, the investigators examines the expression profiles of miRNA machinery components such as miRNA maturation and transport factors, microprocessor complex and RISC subunits in cutaneous melanoma, cutaneous melanoma metastases and benign melanocytic nevi.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2011
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 2008
Date type not reportedThis date has not been verified as actual or estimated.
September 2011
Actual (reported)September 2011
Actual (reported)September 29, 2011
Actual (reported)September 30, 2011
Actual (reported)Patients with cutaneous melanoma, cutaneous melanoma metastases, benign melanocytic nevi
Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum
Bochum, North Rhine-Westphalia, 44791, Germany
Sand M, Skrygan M, Georgas D, Sand D, Gambichler T, Altmeyer P, Bechara FG. The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi. Cell Tissue Res. 2012 Oct;350(1):119-26. doi: 10.1007/s00441-012-1446-0. Epub 2012 Jun 17.
human skin
Falk G Bechara, PD Dr.
Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum
21 participants (actual enrollment reported by the registry).
First Submitted
September 29, 2011
First Posted
September 30, 2011
Study Start
December 2008
Date type not reportedThis date has not been verified as actual or estimated.
Detection of Choroidal Nevus Cells in Vitrectomy Fluid
Intradermal Injection of Anti-CTLA-4 in Patients With Stage I/II Melanoma
Contact the study team to confirm eligibility.
Primary Completion
September 2011
Actual (reported)Study Completion
September 2011
Actual (reported)Last Updated
October 16, 2012
Record last verified: 2012-10
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Source: ClinicalTrials.gov.
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