The Health Effect of Diet Rich in Nordic Berries

NCT01414647 | Completed DMC

• 2 other identifiers: 124//200540361/05
• Study Type: interventional
• Target: 56
• Locations: 1 country
• Sites: 1

Brief Summary

Dietary polyphenols might have beneficial effects on glucose and lipid metabolism based on the studies made in animals or cell cultures. The findings regarding the possible decrease of low-grade inflammation are existing also in humans. Low-grade inflammation has been suggested to be a mechanistic link between obesity and its consequences on cardiometabolic health. The aim of the present study is to examine the effect of diet rich in berries on glucose and lipid metabolism and inflammatory markers.

Conditions

Metabolic Syndrome; Impaired Glucose Tolerance; Low-grade Inflammation; Dyslipidemia

Keywords

Bilberry; Vaccinium myrtillus; Metabolic syndrome; Glucose metabolism; Lipid metabolism; Inflammation; Gene expression

Outcome Measures

Primary Outcomes (3)

• Glucose level

  Fasting glucose level oral glucose tolerance status at study week 8

  week 8

• Cholesterol level

  total, HDL and LDL cholesterol level at the study week 8

  week 8

• Inflammation markers

  Various inflammation markers were measured at the study week 8

  week 8

Secondary Outcomes (2)

• Markers of sterol metabolism

  week 8

• gene expression in PBMCs

  study week 8

Study Arms (3)

SRC

EXPERIMENTAL

Strawberry, raspberry and cloudberry intervention for 8 weeks

Dietary Supplement: 300 g of strawberry, raspberry and cloudberry

BB

EXPERIMENTAL

Bilberry intervention for 8 weeks

Dietary Supplement: 400 g of bilberry

C

EXPERIMENTAL

Control diet with restricted berry consumption

Other: Control diet

Interventions

300 g of strawberry, raspberry and cloudberry DIETARY_SUPPLEMENT

100 g of strawberry puree, 100 g of frozen raspberries and 100 g frozen cloudberries were concumed daily for 8 weeks. Bilberry consumption was restricted.

SRC

400 g of bilberry DIETARY_SUPPLEMENT

Equivalent amount to 400 g of fresh bilberries were consumed as 40 g of dried bilberries and as 200 g of frozen bilberries. Restriction of use of strawberries, raspberries and cloudberries were set.

BB

Control diet OTHER

Control diet, ie. habitual diet with restriction of berry consumption was consumed for eight weeks

Also known as: Diet with restricted consumption of berries.

C

Eligibility Criteria

• Age: 50 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• overweight (BMI 26-39 kg/m2), and two of the following:
• elevated fasting plasma glucose in the absence of diabetes (5.6-6.9 mmol/l)
• abnormal serum lipid concentration: fasting serum triglyceride concentration \>1.7 mmol/L, fasting serum HDL cholesterol \<1.0 mmol/L (males) or \<1.3 mmol/L (females))
• waist circumference \>102 cm (males) or \>88 cm (females)
• blood pressure \>130/85 mmHg

You may not qualify if:

• chronic diseases
• use of lipid lowering medication

Sponsors & Collaborators

• Marjukka Kolehmainen: lead
• VTT Technical Research Centre, Finland: collaborator

Study Sites (1)

University of Eastern Finland, Dpet of Public Health and Clinical Nutrition

Kuopio, FIN-70211, Finland

Location

Related Publications (2)

• Puupponen-Pimia R, Seppanen-Laakso T, Kankainen M, Maukonen J, Torronen R, Kolehmainen M, Leppanen T, Moilanen E, Nohynek L, Aura AM, Poutanen K, Tomas-Barberan FA, Espin JC, Oksman-Caldentey KM. Effects of ellagitannin-rich berries on blood lipids, gut microbiota, and urolithin production in human subjects with symptoms of metabolic syndrome. Mol Nutr Food Res. 2013 Dec;57(12):2258-63. doi: 10.1002/mnfr.201300280. Epub 2013 Aug 12.

  PMID: 23934737 DERIVED

• Kolehmainen M, Mykkanen O, Kirjavainen PV, Leppanen T, Moilanen E, Adriaens M, Laaksonen DE, Hallikainen M, Puupponen-Pimia R, Pulkkinen L, Mykkanen H, Gylling H, Poutanen K, Torronen R. Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome. Mol Nutr Food Res. 2012 Oct;56(10):1501-10. doi: 10.1002/mnfr.201200195. Epub 2012 Sep 7.

  PMID: 22961907 DERIVED

MeSH Terms

Conditions

Metabolic Syndrome; Glucose Intolerance; Dyslipidemias; Inflammation

Interventions

Vaccinium myrtillus extract; Diet

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Hyperglycemia; Lipid Metabolism Disorders; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Riitta Törrönen, Adjunct Professor

  University of Eastern Finland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Senior scientist

Study Record Dates

• First Submitted: August 10, 2011
• First Posted: August 11, 2011
• Study Start: January 1, 2006
• Primary Completion: December 1, 2006
• Study Completion: March 1, 2010
• Last Updated: May 17, 2018

Record last verified: 2018-05

Locations

FI (1)