Database Registry for Neural Network Biomarkers in Psychosis
Imaging
Database Registry to Examine Brain Connections and Brain Function in Mental Disorders and Neural Network Biomarkers for Relational Memory and Psychosis in Schizophrenia
3 other identifiers
observational
1,000
1 country
1
Brief Summary
Several observations have been made with magnetic resonance imaging (MRI) that characterize brain connections and brain function in individuals with schizophrenia and other mental disorders. For example, research investigating schizophrenia focuses on the dysfunction of connections within and between the medial temporal lobe and the prefrontal cortex as well as other pertinent brain regions. This database registry will allow for the collection of clinical interview data, behavioral data, blood, magnetic resonance imaging (MRI) data, and functional magnetic resonance imaging (fMRI) data on individuals with and without mental disorders to better understand how connections in the brain and various brain regions function differently while volunteers perform various cognitive tasks. This is an observational study that is being conducted to collect data and place it in a registry for current and future investigational questions related to imaging in mental disorders.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2010
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2010
CompletedFirst Submitted
Initial submission to the registry
June 29, 2011
CompletedFirst Posted
Study publicly available on registry
August 3, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
April 1, 2029
April 23, 2026
April 1, 2026
19.1 years
June 29, 2011
April 20, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Differences in hippocampal subfield activation between people with schizophrenia (or schizoaffective disorder) and healthy volunteers
This study will investigate the alterations in the medial temporal lobe, specifically the differences in hippocampal subfield activation, between patients with psychosis (Schizophrenia and Schizoaffective disorder), their relatives and normal volunteers. We hypothesize that there will be an increase in perfusion and a decrease in subfield activation in the people with psychosis.
Participants will be assessed over the course of 4-6 weeks, until all study procedures are complete
Secondary Outcomes (1)
Differences in glutamate neurotransmitters and glutamatergic function between people with schizophrenia (or schizoaffective disorder) and with healthy volunteers
Participants will be assessed over the course of 4-6 weeks, until all study procedures are complete
Study Arms (2)
Patient volunteers
This group is comprised of persons with Schizophrenia and Schizoaffective.
Healthy volunteers
This group is comprised of individuals who have no current or past psychiatric diagnosis.
Eligibility Criteria
Individuals who have been diagnosed with the following disorders will be enrolled in this study: Schizophrenia and Schizoaffective disorder.
You may qualify if:
- Volunteers with Schizophrenia or other mental illness
- Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnosis of Schizophrenia or Schizoaffective disorder
- Competent to give informed consent
- All races and ethnicities
- Eyesight corrected to 20-40 or better
- Able to read, speak, and understand English
- Healthy volunteers
- No past or current severe mental illness
- All races and ethnicities
- Eyesight corrected to 20-40 or better
- Able to read, speak, and understand English
You may not qualify if:
- Volunteers with schizophrenia or other mental illness
- Diagnosis of an organic brain disease
- Diagnosis of DSM-IV-TR alcohol or substance abuse within the last month or DSM-IV-TR alcohol or substance dependence within the last three months
- Serious, unstable medical illness
- History of serious head injury
- Pregnant women
- Healthy volunteers
- History of psychiatric illness
- Current use of psychoactive drugs excluding nicotine and caffeine
- Diagnosis of an organic brain disease
- Serious, unstable medical illness
- History of serious head injury
- Pregnant women
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Carol A. Tamminga, M.D.
UT Southwestern
- PRINCIPAL INVESTIGATOR
Elena Ivleva, M.D., Ph.D.
UT Southwestern
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
June 29, 2011
First Posted
August 3, 2011
Study Start
March 1, 2010
Primary Completion (Estimated)
April 1, 2029
Study Completion (Estimated)
April 1, 2029
Last Updated
April 23, 2026
Record last verified: 2026-04