Cough Frequency in Chronic Obstructive Pulmonary Disease

NCT01405222 | Completed

• 1 other identifier: 25042011
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Acute exacerbations of COPD remain a common cause of morbidity and are associated with a sustained increase in the normal respiratory symptoms of dyspnoea, cough, and sputum volume and purulence. It has previously been shown that a change in cough symptoms occurs in 51.7% of exacerbations in COPD. We wish to record cough during a COPD exacerbation to determine whether this can be a objective marker of exacerbation duration and severity.

Conditions

COPD Exacerbation

Keywords

exacerbation; COPD; Cough

Outcome Measures

Primary Outcomes (1)

• Change in recorded cough counts/hr

  The primary objective is to evaluate the effectiveness of Hull Automated Cough Counter in recording transition of an acute COPD exacerbation. Change in no coughs/hr will be measured between start of exacerbation (day 0) to day 5 of exacerbation

  5 days

Secondary Outcomes (1)

• compare cough/hr measured via Hull automated cough counter with that of Phillips 45 day cough monitor

  45 days

Study Arms (1)

Acute COPD exacerbation

Patients admitted in to hospital with an acute exacerbation of COPD

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospital admissions

You may qualify if:

• Male/females aged between 40-80 years.
• Previous diagnosis of COPD.
• Acute exacerbation of COPD requiring treatment with antibiotics and/or corticosteroids.
• Symptoms of increased breathlessness, cough, sputum volume or sputum purulence.
• Acute exacerbation of COPD hospitalised within 48 hrs of study participation.
• Known history of cigarette smoking at least 10 pack yrs.
• Willing and able to comply with study procedures.
• Able to provide written informed consent to participate.

You may not qualify if:

• Clinically significant or unstable concurrent disease e.g. left ventricular failure, diabetes mellitus.
• On long-term oxygen therapy.

Sponsors & Collaborators

• Hull University Teaching Hospitals NHS Trust: lead
• Philips Respironics: collaborator

Study Sites (1)

Redspiratory medicine, Clinical trials Unit, Castle Hill hospital

Cottingham, East Yorkshire, HU16 5JQ, United Kingdom

Location

Related Publications (1)

• Crooks MG, den Brinker A, Hayman Y, Williamson JD, Innes A, Wright CE, Hill P, Morice AH. Continuous Cough Monitoring Using Ambient Sound Recording During Convalescence from a COPD Exacerbation. Lung. 2017 Jun;195(3):289-294. doi: 10.1007/s00408-017-9996-2. Epub 2017 Mar 28.

  PMID: 28353117 RESULT

Related Links

• Publication Link

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Cough

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Officials

• Alyn H Morice, MD, MPhil

  Hull University Teaching Hospitals NHS Trust

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 28, 2011
• First Posted: July 29, 2011
• Study Start: January 1, 2012
• Primary Completion: June 1, 2013
• Study Completion: July 1, 2013
• Last Updated: July 15, 2019

Record last verified: 2019-07

Locations

GB (1)