MgSO4 Combined With Rocuronium Priming
1 other identifier
interventional
100
1 country
1
Brief Summary
Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2011
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2011
CompletedFirst Submitted
Initial submission to the registry
May 26, 2011
CompletedFirst Posted
Study publicly available on registry
July 8, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2012
CompletedJanuary 10, 2012
January 1, 2012
8 months
May 26, 2011
January 6, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
time from injection of induction dose of rocuronium until 95% depression of TOF
time from injection of induction dose of rocuronium until 95% depression of TOF, upto 5 min
Secondary Outcomes (2)
rocuronium duration
time from injection of induction dose of rocuronium until train-of-four count reaches two.
intubating condition
time from injection of induction dose of rocuronium until tracheal intubation.
Study Arms (4)
Roc
NO INTERVENTIONPatients in this group receive neither MgSO4 nor priming dose of rocuronium.
priming
ACTIVE COMPARATORpatients in this group receive 0.06mg/kg of rocuronium before 0.54mg/kg of rocuronium.
Mg&priming
EXPERIMENTALPatients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
MgSO4
ACTIVE COMPARATORPatients in this group receive intravenous MgSO4 before administration of rocuronium.
Interventions
Patients in this group receive intravenous MgSO4 50mg/kg before administration of rocuronium (induction dose).
Patients in this group receive 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
Eligibility Criteria
You may qualify if:
- patients of ASA Ⅰ-Ⅱ
- aged 18\~65
- scheduled to undergo elective surgery under general anesthesia
You may not qualify if:
- risk of pulmonary aspiration
- anticipated airway difficulty
- reactive airway disease
- allergic to study drugs
- neuromuscular / cardiovascular/ renal/ hepatic disease
- atrioventricular conduction disturbance
- BMI \< 18.5 or \> 24.9
- chronic treatment with calcium channel blocker
- medications which affect muscle relaxation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Seoul national university Bundang hospital
Seongnam, Kyoung-ki-do, 463-707, South Korea
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Sanghwan Do, M.D., PH.D.
Seoul National University Bundang Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- full instructor
Study Record Dates
First Submitted
May 26, 2011
First Posted
July 8, 2011
Study Start
May 1, 2011
Primary Completion
January 1, 2012
Study Completion
January 1, 2012
Last Updated
January 10, 2012
Record last verified: 2012-01