Migraine and Endothelial Dysfunction
1 other identifier
observational
60
1 country
1
Brief Summary
Recently, there is evidence that endothelial activation and dysfunction are associated with migraine, especially in female migraineurs with aura. Our objectives were to determine whether novel endothelial function markers are altered in female migraineurs with aura compared to age-matched controls.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Oct 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2010
CompletedFirst Submitted
Initial submission to the registry
July 5, 2011
CompletedFirst Posted
Study publicly available on registry
July 7, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedJuly 18, 2018
July 1, 2018
10 months
July 5, 2011
July 16, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Endothelial Microparticles
Levels of endothelial microparticlel in the peripheral blood using flow cytometry
baseline
Secondary Outcomes (2)
Levels of circulating Endothelial Progenitor Cells
baseline
Digital pulse volume change
baseline
Study Arms (2)
migraine group
female migraineurs with aura
control group
healthy women without headache syndrome
Eligibility Criteria
female migraineurs from outpatient clinic
You may qualify if:
- migraine with aura
- age \< 50
- female gender
You may not qualify if:
- severe infectious disease
- cardiovascular disease (stroke, coronary heart disease, myocardial infarction)
- vasculitis
- peripheral artery disease
- diabetes mellitus
- pregnancy
- drug abuse
- medication: statin, anticoagulation, aspirin, clopidogrel
- intake of triptans \<24h
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Center for Stroke Research Berlin
Berlin, 10117, Germany
Related Publications (3)
Liman TG, Neeb L, Rosinski J, Wellwood I, Reuter U, Doehner W, Heuschmann PU, Endres M. Peripheral endothelial function and arterial stiffness in women with migraine with aura: a case-control study. Cephalalgia. 2012 Apr;32(6):459-66. doi: 10.1177/0333102412444014. Epub 2012 Apr 20.
PMID: 22523187BACKGROUNDLiman TG, Bachelier-Walenta K, Neeb L, Rosinski J, Reuter U, Bohm M, Endres M. Circulating endothelial microparticles in female migraineurs with aura. Cephalalgia. 2015 Feb;35(2):88-94. doi: 10.1177/0333102414529671. Epub 2014 Apr 8.
PMID: 24715500BACKGROUNDLiman TG, Neeb L, Rosinski J, Reuter U, Endres M. Stromal Cell-Derived Factor-1 Alpha Is Decreased in Women With Migraine With Aura. Headache. 2016 Sep;56(8):1274-9. doi: 10.1111/head.12839. Epub 2016 May 30.
PMID: 27238143BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Thomas Liman, MD
Center for Stroke Research Berlin, Charité Campus Mitte
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD MSC
Study Record Dates
First Submitted
July 5, 2011
First Posted
July 7, 2011
Study Start
October 1, 2010
Primary Completion
August 1, 2011
Study Completion
December 1, 2011
Last Updated
July 18, 2018
Record last verified: 2018-07