NCT01379950|Unknown
Role of Macrophage in Inflammation Resolution in Periodontal Patients
The Role of Macrophages in the Inflammatory Resolution Phase in Periodontal Patients
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The Role of Macrophages in the Inflammatory Resolution Phase in Periodontal Patients
Sponsor study identifier
observational
30
1 country
1
Study Start
August 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
August 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
There is a growing body of evidence to suggest that the resolution of an inflammatory reaction is an active process. This process requiring signals that turn off early inflammatory stages, as neutrophil infiltration and promote resolution phase, as clearance of apoptotic cells. In this array,the relationship between neutrophils, monocytes, and macrophages is crucial for the concert process. Macrophages possess a plasticity of phenotype that explains their protective as well as potentially detrimental role in chronic inflammation and tissue injury. Such heterogeneity arises as macrophages differentiate from monocytes and are exposed to specific tissue- and hematopoietic cell-derived stimuli. It is important to be able to identify the different types of macrophages in this setting. Today's literature can distinguish between 3 main phenotypic groups of macrophages. The classically activated M1 macrophages, the alternatively activated-M2 macrophages and the "resolution phase" - rMs macrophages. The third phenotypic macrophage might play a crucial rule in the resolution phase, and is called the "resolving macrophage". All of those pro-resolving lipid mediators promote the return to tissue homeostasis . The investigators hypothesis is that in periodontal patients the inflammatory process continues because the process does not reach the resolution phase, and in that milieu, the macrophage might be a key component. Within the overall concept of periodontal disease as a model for an inflammatory disease with an stoppable inflammatory reaction, the primary aim of the study is to check the macrophage characteristics in periodontal patients and to compare it to healthy people.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 25, 2011
Actual (reported)June 23, 2011
Actual (reported)August 2011
Date type not reportedThis date has not been verified as actual or estimated.
August 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
August 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The macrophage phenotype (M1, M2, resolution phase macrophage)
we will try to specify the characteristics of the macrophage phenotype and to see whether there is a difference between periodontal patients and healthy ones.
1 year
patients diagnosed with periodontal disease
patients coming to the periodontal clinic in the dental school in order to attend a periodontal treatment
Periodontal Clinic, Faculty of Dental Medicine, Hebrew University and Hadassah Medical Center
Jerusalem, Israel
Bystrom J, Evans I, Newson J, Stables M, Toor I, van Rooijen N, Crawford M, Colville-Nash P, Farrow S, Gilroy DW. Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP. Blood. 2008 Nov 15;112(10):4117-27. doi: 10.1182/blood-2007-12-129767. Epub 2008 Sep 8.
First Submitted
May 25, 2011
First Posted
June 23, 2011
Study Start
August 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2012
Estimated (date passed)Interdental Plaque Reduction and Periodontitis
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This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
August 2012
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
June 23, 2011
Record last verified: 2011-06
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