DNA Methylation and Urothelial Carcinoma
Level of DNA Methylation in People With Urothelial Carcinoma
1 other identifier
observational
200
1 country
1
Brief Summary
Many studies previously showed the significant association between urinary arsenic profiles and urothelial carcinoma (UC) risk and observed the increased UC risk in people with lower plasma folate and higher homocysteine than those with higher plasma folate and lower homocysteine. The investigators would expect to explore the interactions among global DNA methylation, one-carbon metabolic pathway factors, urinary arsenic profiles and UC.
Trial Health
Trial Health Score
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participants targeted
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2011
CompletedFirst Submitted
Initial submission to the registry
June 20, 2011
CompletedFirst Posted
Study publicly available on registry
June 22, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2012
CompletedJune 22, 2011
June 1, 2011
1 year
June 20, 2011
June 21, 2011
Conditions
Outcome Measures
Primary Outcomes (1)
urothelial carcinoma
Pathological verification of UC was done by routine urological practice including endoscopic biopsy or surgical resection of urinary tract tumors followed by histopathological examination by board-certified pathologists.
one year
Study Arms (2)
urothelial carcinoma pateints
healthy controls
Age and gender matched control subjects with no evidence of UC or any other malignancy were accrued from the hospital, recruiting people receiving adult health examinations at China Medical University Hospital.
Eligibility Criteria
This is a hospital-based case-control study. Patients with urothelial carcinoma are recruited by pathological verification of UC was done by routine urological practice including endoscopic biopsy or surgical resection of urinary tract tumors followed by histopathological examination by board-certified pathologists. Healthy controls without evidence of UC or any other malignancy were recruited including those receiving adult health examinations at China Medical University Hospital.
You may qualify if:
- Clinical diagnosis of urothelial carcinoma
- The voluntary of participating the study
You may not qualify if:
- Age smaller than 20 years
- Pregnant women
- Not willing to participate the study because of their personal reasons
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Urology, China Medical University Hospital
Taichung, 404, Taiwan
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Chi-Jung Chung, PhD
Department of Health risk Management, China Medical University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
June 20, 2011
First Posted
June 22, 2011
Study Start
June 1, 2011
Primary Completion
June 1, 2012
Last Updated
June 22, 2011
Record last verified: 2011-06