The Changes of Tissue Oxygen Saturation Under Spinal Anesthesia

NCT01377259 | Unknown

• 1 other identifier: 200808010R
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Neuraxial anesthesia affords a less interventional way to desensitization of the lower body for surgical procedures. After introduction of neuraxial anesthesia, vasodilatation of body part below the anesthetic level is theoretically appeared as the sympathetic nerve efferent is blocked. The vasodilatation effect is related to hypotension, hypothermia, shivering and the response of volume redistribution. It is believed that vasodilatation leads to better regional tissue perfusion and better regional tissue oxygenation. Previous reports of laser doppler flowmetry and thermography showed their effectiveness on monitoring blocked level but they were not easily available in the operation room. Recently Near-infrared spectroscopy(NIRS) demonstrates real-time tissue oxygen saturation(rSO2) which is applied generally in non-invasive brain oximeter. We use NIRS in spinal anesthesia to monitor the tissue oxygenation change over the upper and lower limbs during the induction of neuraxial anesthesia.

Conditions

Anesthesia

Keywords

changes; tissue; oxygenation; saturation; between; upper; lower; extremities; patients; Adverse Effect; Spinal and Epidural

Study Arms (2)

1Tissue oxygenation change

Spinal anesthesia may result different changes of tissue oxygenation in blocked area ( upper extrimities ) and non-blocked area ( lower extrimities). The changes of tissue oxygenation saturation between upper and lower extremities in patients under spinal anesthesia for orthopedic surgery

Other: tissue oxygen saturation, spinal anesthesia

2Tissue oxygenation change

The changes of tissue oxygenation saturation between upper and lower extremities in patients under spinal anesthesia for cesarean section

Other: tissue oxygen saturation, spinal anesthesia

Interventions

tissue oxygen saturation, spinal anesthesia OTHER

regional tissue oxygen saturation(rSO2)detected over upper and lower extremities before and after spinal anesthesia

Also known as: NIRS model - INVOS(Somanetics) 5100B Cerebral Oximetry

1Tissue oxygenation change; 2Tissue oxygenation change

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who receive operations under spinal anesthesia

You may qualify if:

• patients who receive operations under spinal anesthesia

You may not qualify if:

• neurological, cardiovascular diseases

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taipei, 100, Taiwan

RECRUITING

MeSH Terms

Interventions

Anesthesia, Spinal

Intervention Hierarchy (Ancestors)

Anesthesia, Conduction; Anesthesia; Anesthesia and Analgesia

Study Officials

• ya-jung cheng

  department of anesthesiology, national taiwan university nospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ya-jung Cheng, MD.,PhD.

CONTACT

886-2-23123456; chengyj@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: September 14, 2008
• First Posted: June 21, 2011
• Study Start: September 1, 2008
• Primary Completion: December 1, 2009
• Study Completion: June 1, 2011
• Last Updated: June 21, 2011

Record last verified: 2011-05

Locations

TW (1)