Safety and Tolerability of DS-7423 in Subjects With Advanced Solid Malignant Tumors

NCT01364844 | Completed Phase 1

• 1 other identifier: DS7423-A-U101
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 3

Brief Summary

This will be a Phase 1, open-label study of DS-7423 to assess its safety and tolerability, identify a RP2D, (recommended Phase 2 Dose) and assess its Pharmacokinetics (PK) (what your body does to process the drugs and how your body gets them out of your system.) and pharmacodynamics (PDy) (Pharmacodynamics is a study of what a drug does to your body) properties in subjects with advanced solid malignant tumors. This study will include 2 parts: part 1-Dose Escalation and part 2-Dose Expansion. Study Hypothesis: DS-7423 will be safe and tolerable, and will exhibit acceptable PK and PDy properties in subjects with advanced solid malignant tumors for whom standard therapy has failed or for whom no standard therapy exists.

Conditions

Solid Tumor; Colorectal Cancer; Endometrial Cancer

Outcome Measures

Primary Outcomes (1)

• Adverse Events

  All adverse events will be graded according to the NCI-CTCAE, version 4.0

  30 days after last dose

Secondary Outcomes (6)

• Plasma pharmacokinetics of DS-7423

  Cycle 1 - days 1, 2, 8, and 15; Cycle 2 - day 1; end of study

• Effects of DS-7423 on glucose metabolism

  Cycle 1 Days 1, 2, and 15; and end-of-study

• Pharmacodynamic effects of DS-7423 in surrogate tissues

  Cycle 1 Days 1, 2, and 15

• Pharmacodynamic effects of DS-7423 in tumors

  Baseline and Cycle 1 Day 4

• Part 2 - Objective response rate in subjects with advanced colorectal and endometrial cancer

  Baseline and every 2 cycles of treatment for the first 8 cycles and then every 3 cycles thereafter until study drug discontinuation

Study Arms (1)

DS7423

EXPERIMENTAL

Drug: DS-7423

Interventions

DS-7423 DRUG

oral capsule 1mg, 8mg, 48mg, and 80mg strengths administered once daily

DS7423

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• A pathologically documented advanced solid malignant tumor refractory to standard treatment or for which no standard treatment is available
• Eastern Cooperative Oncology Group (ECOG) performance status =\< 1
• Have adequate bone marrow function, defined as:
• Platelet count \>= 100 X 10\^9/L Hemoglobin (Hb) level \>= 9.0 g/dL ANC \>= 1.5 X 10\^9/L - Have adequate renal function, defined as: Creatinine clearance \>= 60 mL/min, as calculated using the modified Cockroft Gault equation, (\[{140 - age in yrs} x {actual weight in kg}\] divided by \[{72 x serum creatinine in mg/dL} multiply by 0.85 if female\]), or creatinine =\< 1.5 X ULN
• \- Have adequate hepatic function, defined as: AST/ALT levels =\< 3 X ULN (if liver metastases are present, =\< 5 X ULN) Bilirubin =\< 1.5 X ULN
• \- Have adequate blood clotting function, defined as: Prothrombin time and activated partial thromboplastin time =\< 1.5 X ULN
• Subjects should be able to provide written informed consent, comply with protocol visits and procedures, be able to take oral medication, and not have any active infection or chronic comorbidity that would interfere with therapy
• Subjects (male and female) of childbearing potential must agree to use double-barrier contraceptive measures or avoid intercourse during the study and for 90 days after the last dose of study drug
• Subjects must be fully informed about their illness and the investigational nature of the study protocol (including foreseeable risks and possible side effects) and must sign and date an Institutional Review Board (IRB) approved informed consent form (ICF) (including Health Insurance Portability and Accountability Act (HIPAA) authorization, if applicable) before performance of any study-specific procedures or tests
• Subjects must be willing to provide available preexisting diagnostic or resected tumor samples, such as formalin-fixed paraffin-embedded sections. Providing fresh tumor biopsy is optional for subjects in dose escalation cohorts. Pre- and posttreatment biopsies are optional for all the subjects in Dose Escalation cohorts but required for those in Dose Expansion cohorts
• A pathologically documented advanced colorectal or endometrial cancer, with measurable disease based on RECIST criteria, Version 1.1, that is refractory to standard treatment
• Agree to undergo pre- and posttreatment tumor biopsies

You may not qualify if:

• History of second malignancy and primary central nervous system malignancies, except adequately treated nonmelanoma skin cancer, curatively treated in situ disease, or other solid tumors curatively treated, with no evidence of disease for \>= 3 years
• Gastrointestinal diseases that could affect the absorption of DS-7423
• Subjects with a fasting glucose \> 126 mg/dL (\> 7 mmol/L)
• History of diabetes mellitus (Type I or II) or hemoglobin A1c (HbA1c) \> 7.0%
• Tested positive for hepatitis B or C serological markers (HBsAg or antiHCV)
• Recipient of live vaccine within 1 month of or during study drug treatment
• Concomitant use of chronic systemic corticosteroids
• Subjects requiring daily supplemental oxygen
• Recipient of a stem cell or bone marrow transplant
• Has a concomitant medical condition that would increase the risk of toxicity, in the opinion of the investigator or sponsor
• Clinically active brain metastases, defined as untreated and symptomatic, or requiring therapy with steroids or anticonvulsants to control associated symptoms. Subjects with treated brain metastases that are no longer symptomatic and who require no treatment with steroids may be included in the study if they have recovered from the acute toxic effect of radiotherapy. A minimum of 4 weeks must have elapsed between the end of whole brain radiotherapy and study enrollment (2 weeks for stereotactic radiotherapy)
• Has unresolved toxicities from previous anticancer therapy, defined as toxicities (other than alopecia) not yet resolved to NCI CTCAE, Version 4.0, grade =\< 1 or baseline. Subjects with chronic grade 2 toxicities may be eligible per the discretion of the investigator or sponsor (eg, grade 2 chemotherapy-induced neuropathy)
• Systemic treatment with anticancer therapy, antibody-based therapy, retinoid therapy, or hormonal therapy within 3 weeks before study drug treatment; or treatment with nitrosoureas or mitomycin C within 6 weeks before study drug treatment; or treatment with small-molecule targeted agents within 2 weeks, or 5 half-lives before study drug treatment, whichever is longer. Previous and concurrent use of hormone replacement therapy, the use of gonadotropin-releasing hormone modulators for prostate cancer, and the use of somatostatin analogs for neuroendocrine tumors are permitted if such therapy has not been changed within 60 days before study drug treatment
• Therapeutic radiation therapy or major surgery within 4 weeks before study drug treatment or palliative radiation therapy within 2 weeks before study drug treatment
• Participation in a clinical study within 3 weeks (2 weeks or 5 half-lives, whichever is longer, for small-molecule targeted agents) before study drug treatment, or current participation in other investigational procedures

Sponsors & Collaborators

• Daiichi Sankyo: lead

Study Sites (3)

Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

Location

Memorial Sloan-Kettering Cancer Center

New York, New York, 10065, United States

Location

Sarah Cannon Research Institute

Nashville, Tennessee, 37203, United States

Location

MeSH Terms

Conditions

Colorectal Neoplasms; Endometrial Neoplasms

Interventions

DS7423

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 31, 2011
• First Posted: June 3, 2011
• Study Start: July 1, 2011
• Primary Completion: November 1, 2013
• Study Completion: November 1, 2013
• Last Updated: February 25, 2014

Record last verified: 2014-02

Locations

US (3)