Sunovion Brovana Versus Serevent Inspiratory Capacity High Resolution Computed Tomography

You may not qualify if:

• Presence of other clinically significant illnesses or condition that might interfere with the study, including but not limited to uncontrolled hypertension, cardiovascular disease, cardiac arrhythmia, diabetes, hyperthyroidism, seizure disorder or any history of pheochromocytoma
• History of asthma (in the opinion of the investigator)
• A COPD exacerbations within the past 2 months requiring oral corticosteroids or hospitalization.
• Continuous oxygen therapy greater than 12 hours per day
• Subjects with a body mass index less than 15 or greater than 38
• Known allergy or contradiction to albuterol, arformoterol, salmeterol, tiotropium or prior significant adverse reactions to other beta agonists or ipratropium.
• Inability to withhold other adrenergic drugs (salmeterol, arformoterol, formoterol, albuterol etc.) for an appropriate duration before each visit.
• Ongoing need for drugs which might potentiate hypokalemia (xanthine derivatives (theophylline), steroids, non-potassium sparing diuretics (unless in fixed combination with potassium sparing diuretic)
• Ongoing need for drugs which might cause QTc prolongation (MAO inhibitors, tricyclic antidepressants, cardiac anti-arrhythmics Class Ia (e.g., disopyramide, procainamide, quinidine), or class III (e.g., amiodarone, dofetilide, ibutilide, sotalol), terfenadine, astemizole, mizolastin and any other drug with potential to significantly prolong the QT interval.)
• Ongoing need for beta-blockers (selective or non-selective)
• Use of phenothizines (thioridizine), or other drugs that may interact with arformoterol, salmeterol or albuterol for the duration of the study. Washout of greater than seven half-lives of the drug prior to the study.
• History of angle closure glaucoma, symptomatic prostatic hypertrophy or bladder neck obstruction.
• Investigational drugs within 30 days
• Affiliation with the Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine
• Pregnancy, breastfeeding, planning to become pregnant during study, or woman of childbearing potential unwilling to use adequate contraception