Oral Fluid Volume Expansion
OFVEX
Oral Fluid: Absorption and Expansion of the Blood Volume
1 other identifier
interventional
10
1 country
1
Brief Summary
When subjected to fluid loss or fluid deficiency irrespective of disease or environmental factors it is discussed how to rehydrate or how to hydrate prophylactic. In medical care it is common to give infusions. However it has increasingly become common to hydrate the patient through the mouth even early after bowel surgery. Moreover it is more simple to provide energy the natural way. Which fluid to give, depends on several factors such as possibility to drink, the volume and emptying of the stomach as well as the fluid absorption in the bowel. The provided fluid can also influence this process depending on temperature, osmolality/tonicity and composition (carbohydrates or salts). In this study we wish to study the speed with which the provided fluid is absorbed by the bowels and how fast the fluid is distributed to the different body compartments depending on it's composition. The three fluids will be either tap water, high sodium chloride and a carbohydrate rich fluid.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2011
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2011
CompletedFirst Submitted
Initial submission to the registry
May 23, 2011
CompletedFirst Posted
Study publicly available on registry
May 25, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedMay 14, 2012
May 1, 2012
5 months
May 23, 2011
May 11, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
change in hydration
volume kinetics: calculation from hemoglobin variations
2.5 hours
Secondary Outcomes (1)
fluid kinetic effects of oral carbohydrates
2.5 hours
Study Arms (1)
Tap water, sodium chloride, carbohydrate rich fluid
OTHERInterventions
Ingestion of three different fluids at three different occasions separated by at least one week, A, Tap water. B. Sodium Chloride. C. Carbohydrate rich fluid.
Eligibility Criteria
You may qualify if:
- healthy volunteer
- to 50 years old
You may not qualify if:
- medication
- any chronical disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Intensive Care Unit, University Hospital
Linköping, Sweden
Related Publications (2)
Hahn RG, Wuethrich PY, Zdolsek JH. Can perioperative hemodilution be monitored with non-invasive measurement of blood hemoglobin? BMC Anesthesiol. 2021 May 6;21(1):138. doi: 10.1186/s12871-021-01351-4.
PMID: 33957864DERIVEDZdolsek J, Metander A, Hahn R. Volume kinetic evaluation of fluid turnover after oral intake of tap water, lemonade and saline in volunteers. BMC Sports Sci Med Rehabil. 2016 Jul 28;8:22. doi: 10.1186/s13102-016-0045-x. eCollection 2016.
PMID: 27471593DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Joachim Zdolsek, MD, PhD
University Hospital, Linköping, Sweden
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, PhD
Study Record Dates
First Submitted
May 23, 2011
First Posted
May 25, 2011
Study Start
May 1, 2011
Primary Completion
October 1, 2011
Study Completion
December 1, 2011
Last Updated
May 14, 2012
Record last verified: 2012-05