Study of Methicillin-resistant Staphylococcus Aureus (MRSA) Isolated From Infected Patients in Brazil

NCT01359358 | Unknown DMC

• 1 other identifier: Novartis IFSC-USP
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This project has as general objective to determine if there is any Methicillin-resistant Staphylococcus aureus (MRSA) strain disseminating in the hospital of Belo Horizonte. If this is the case, the investigators will determine if this is an international known strain by typing it by PFGE and MLST. The detection of mecA gene will be performed by PCR. Their susceptibility profile to several drugs will also be accessed and it will be possible to compare the response to those drugs commonly in use to that of Daptomycin, a new drug available in Brazil. It will be screened for reduced susceptibility to vancomycin by Macromethod Etest (MET) in order to search for VISA or hetero-VISA. Also, due to the discussions at the literature about mutations in genes that are said to be responsible for reduced susceptibility to vancomycin, the investigators will sequence these genes in all PFGE type strain of this study looking for mutations already described to compare to the screening results.

Conditions

Methicillin Resistant Staphylococcus Aureus

Keywords

MRSA; MLST; PFGE; Resistance; isolated from colonization

Eligibility Criteria

• Age: 1 Month+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

MRSA from infection or from colonization of a patient who was already infected by MRSA during the time of the study

You may qualify if:

• MRSA from infection sites
• MRSA from colonization of the patients who already was infected by MRSA during the time of the study

You may not qualify if:

• MRSA from colonization of a patient who has not infection caused by MRSA

Sponsors & Collaborators

• University of Sao Paulo: lead

Study Sites (1)

Instituto de Física de Sao Carlos - Universidade de Sao Paulo

São Carlos, São Paulo, 13560-590, Brazil

Location

Study Officials

• Ilana L B Camargo, PhD

  University of Sao Paulo

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Hyllo Baeta MArcelo Jr, Master degree

CONTACT

55 31 99929631; hyllo@lustosa.com.br

Study Design

• Study Type: observational
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 20, 2011
• First Posted: May 24, 2011
• Study Start: July 1, 2011
• Last Updated: May 24, 2011

Record last verified: 2011-05

Locations

BR (1)