The Association Between Different Monocyte Subsets and Coronary Collateral Development

NCT01356836 | Completed DMC

• 1 other identifier: Monocyte subsets
• Study Type: observational
• Target: 105
• Locations: 1 country
• Sites: 1

Brief Summary

Collateral growth and coronary angiogenesis are chronic adaptations to myocardial ischemia. Collateralization helps to restore blood flow and as a result salvages myocardium in severely ischemic myocardial regions. Thus, good collateral development in patients with severe coronary artery disease (CAD) improves ventricular function and prognosis (1-3). However, coronary collateral development is different among patients even with similar degrees of coronary artery stenosis. Several factors, such as diabetes mellitus (4) and duration of myocardial ischemic symptoms (5) have been reported to effect coronary collateral development. At the cellular level, inflammatory cells, especially monocytes have an important role in collateralization. In a series of experimental studies with animals, it has been shown that monocytes are important elements for development of collateral vessels (6-7). In a recent study, it has been demonstrated that increased circulating monocyte count is related to good collateral development in patients with stable coronary artery disease (8). Monocytes in human blood are heterogeneous and can be classified into two subsets according to the presence or absence of the FcγRIII receptor CD16 (9): CD14++CD16- monocytes characterized by high level expression of the CD14 cell surface receptor but no expression of CD16 receptor, and CD14+CD16+ monocytes characterized by the co-expression of CD16 receptor with either high or low level expression of the CD14 receptor. These subsets differ in function and response to several cytokines. Our aim in this study was to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development.

Conditions

Coronary Artery Disease; Coronary Ischemia

Keywords

Coronary collateral development; monocyte subsets; collateralization

Study Arms (2)

Good-poor collateral

Patients who had good and poor collaterals formed 2 groups

Good collateral, Poor collateral

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients who were found to have \>95% stenosis of at least one major coronary artery in their first coronary angiogram were included in this study.

You may qualify if:

• \> 95% stenosis of at least one major coronary artery in their first coronary angiogram

You may not qualify if:

• previous percutaneous or surgical revascularization history
• evidence of ongoing infection and inflammation
• known malignancy and chronic kidney disease (serum creatinine \> 1.5 mg/dl
• diabetic patients

Sponsors & Collaborators

• Yuksek Ihtisas Hospital: lead

Study Sites (1)

1Türkiye Yüksek İhtisas Education and Research Hospital, Department of Cardiology

Ankara, 06550, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 17, 2011
• First Posted: May 20, 2011
• Study Start: January 1, 2011
• Primary Completion: May 1, 2011
• Study Completion: May 1, 2011
• Last Updated: May 20, 2011

Record last verified: 2011-03

Locations

TU (1)