The Effect of Natural Food Flavourings on Gastrointestinal and Cardiovascular Physiological Responses.
CinnGastEmpt
Effect of Cinnamon on Gastric Emptying, Arterial Stiffness, Postprandial Lipaemia, Glycaemia, and Appetite Responses to High-fat Breakfast
1 other identifier
interventional
9
1 country
1
Brief Summary
The purpose of this study is to determine whether 3 g cinnamon was sufficient to delay the gastric emptying rate of a high-fat solid meal and subsequently reduce postprandial blood glucose and lipid responses, oxidative stress, arterial stiffness and satiety responses in a healthy adult population.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jun 2009
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2010
CompletedFirst Submitted
Initial submission to the registry
May 3, 2011
CompletedFirst Posted
Study publicly available on registry
May 9, 2011
CompletedMay 9, 2011
May 1, 2011
1 month
May 3, 2011
May 6, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The effect of 3grams cinnamon on gastric emptying half time
During the 6.5 hours post ingestion
Secondary Outcomes (6)
Arterial stiffness
During the 6.5 hours after ingestion
Lipaemia
During the 6.5 hours after ingestion
Glycemia
During the 6.5 hours after ingestion
Appetite
During the 6.5 hours after ingestion
Oxidative stress
During the 6.5 hours after ingestion
- +1 more secondary outcomes
Study Arms (1)
Dietary supplementation
EXPERIMENTAL3g of cinnamon or placebo control were added to a test-meal.
Interventions
3 g wheat flour (placebo)- separated by 28 days from cinnamon intervention
Eligibility Criteria
You may qualify if:
- Healthy adults aged 18-35 years
- Recreationally trained individuals (participate in at least 2hrs/wk of individual/team sport)
- Not currently taking antioxidant or lipid-lowering medication
- Fasting blood lipid, glucose and blood pressure (BP) levels were all within the normal limits.
You may not qualify if:
- History of gastrointestinal-related conditions, diabetes mellitus or cardiovascular disease.
- Allergies to foods in study.
- Blood disorder
- Pregnancy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Limericklead
- University of Ulstercollaborator
- Ulster Hospital, Northern Irelandcollaborator
- National University of Ireland, Galway, Irelandcollaborator
Study Sites (1)
Department of Physical Education & Sport Sciences, University of Limerick
Limerick, Ireland
Related Publications (1)
Markey O, McClean CM, Medlow P, Davison GW, Trinick TR, Duly E, Shafat A. Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. Cardiovasc Diabetol. 2011 Sep 7;10:78. doi: 10.1186/1475-2840-10-78.
PMID: 21899741DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Amir Shafat, PhD
Univeristy of Limerick
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 3, 2011
First Posted
May 9, 2011
Study Start
June 1, 2009
Primary Completion
July 1, 2009
Study Completion
March 1, 2010
Last Updated
May 9, 2011
Record last verified: 2011-05