Regional Fat Depots and Insulin Resistance
Heterogeneity of Fat Depots
1 other identifier
observational
166
1 country
1
Brief Summary
The biological basis for insulin resistance associated with obesity is unknown. By studying equally-overweight/obese individuals who are either insulin resistant or insulin sensitive, the investigators will compare characteristics of fat tissue to test several hypotheses: 1) impaired differentiation and fat storage in the subcutaneous fat depot characterize insulin resistant individuals, who have, as a result, fat in other tissues like liver and muscle, as well as more fat circulating in the blood; 2) inflammation is greater in visceral and/or subcutaneous adipose tissue depots in insulin resistant individuals as compared with insulin sensitive individuals.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Aug 2009
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2009
CompletedFirst Submitted
Initial submission to the registry
March 30, 2011
CompletedFirst Posted
Study publicly available on registry
April 18, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2013
CompletedDecember 4, 2024
December 1, 2024
3.8 years
March 30, 2011
December 2, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Adipose Cell Size
Harvest adipose tissue from human biopsy. Prepare for cell size analysis using Beckman Multisizer Coulter Counter
3 years
Secondary Outcomes (2)
Macrophage density
3 years
Gene Expression
3 years
Study Arms (2)
Insulin resistant group
there is no intervention
Insulin sensitive group
There is no intervention
Eligibility Criteria
Healthy, nondiabetic volunteers will be recruited from Stanford's General Surgery Preoperative Clinic, Stanford's Bariatric Surgery Clinic, and nonsurgical volunteers who respond to local newspaper advertisements.
You may qualify if:
- No major organ disease
- Fasting blood glucose \< 126 mg/dL
- BMI 25-35 kg/m2
- Nonpregnant/nonlactating
You may not qualify if:
- pregnancy/lactation
- major organ disease
- drugs that influence insulin resistance
- unstable body weight or active weight loss program
- outside BMI range or age range
- diabetic by fasting glucose criteria 126 mg/dL or higher
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Stanford Universitylead
- University of Californiacollaborator
- National Institutes of Health (NIH)collaborator
Study Sites (1)
Stanford University
Stanford, California, 94305, United States
Related Publications (1)
McLaughlin T, Lamendola C, Liu A, Abbasi F. Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity. J Clin Endocrinol Metab. 2011 Nov;96(11):E1756-60. doi: 10.1210/jc.2011-0615. Epub 2011 Aug 24.
PMID: 21865361DERIVED
Biospecimen
adipose tissue samples will be frozen for gene expression analysis.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
March 30, 2011
First Posted
April 18, 2011
Study Start
August 1, 2009
Primary Completion
May 1, 2013
Study Completion
May 1, 2013
Last Updated
December 4, 2024
Record last verified: 2024-12