Exercise, Age-Related Memory Decline, And Hippocampal Function

NCT01329653 | Completed DMC

• 2 other identifiers: #6219/#7161RAG035015
• Study Type: interventional
• Target: 233
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test the hypothesis that aerobic exercise leads increased cerebral blood volume in the dentate gyrus of the hippocampus in a sample of young and older adults.

Conditions

Cognitive Deterioration; Disorder of Aging

Keywords

cerebral blood volume; aging; exercise

Outcome Measures

Primary Outcomes (1)

• dentate gyrus cerebral blood volume

  change from before (pre) to after (post) 12 weeks of training

Secondary Outcomes (3)

• cognitive function

  change from before (pre) to after (post) 12 weeks of training

• aerobic capacity

  change from before (pre) to after (post) 12 weeks of training

• cerebral blood flow

  change from before (pre) to after (post) 12 weeks of training

Study Arms (2)

aerobic training

EXPERIMENTAL

12 weeks of aerobic training, 4X/week

Behavioral: aerobic training

wait list control

PLACEBO COMPARATOR

wait list control condition, 12 weeks to parallel the active intervention group

Behavioral: Wait list

Interventions

aerobic training BEHAVIORAL

12 weeks of aerobic training, 4X/week

aerobic training

Wait list BEHAVIORAL

wait list control condition

Also known as: Wait list control

wait list control

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 20-75 years
• English-speaking
• Ambulatory
• "Average" fitness as determined by ACSM's Guidelines for Exercise Testing and Prescription (for men, VO2max \< 43 for age 20-39 years, \< 38 for age 40-49 years, \< 35 for age 50-59, \< 31 for age 60-75; for women, \< 36 for age \< 30 years, \< 34 for age 30-39 years, \< 32 for age 40-49 years, \<25 for age 50-59 years, \< 24 for age 60-75 years
• BMI \<35

You may not qualify if:

• Ischemic changes or abnormal resting cardiogram, abnormal blood pressure responses, or an significant ectopy during aerobic capacity testing
• Cardiovascular disease
• BMI \> 35
• Uncontrolled high blood pressure (systolic blood pressure ≥ 140 mmHg; or diastolic blood pressure ≥ 90mmHg on two measures)
• Any condition for which aerobic training is counter-indicated, including persons with evidence or history of medical or orthopedic conditions which might make participation problematic.
• Active hepatic disease (not a history of hepatitis) or primary renal disease requiring dialysis, primary untreated endocrine diseases, e.g., Cushing's disease or primary hypothalamic failure or insulin dependent diabetes (Type I or II). Welltreated hypothyroidism will not be excluded.
• History of chemotherapy
• HIV infection
• Pregnant or lactating (participation allowed 3 months after ceasing lactation).
• Medications that alter inflammation or autonomic nervous system activity
• Any history of psychosis or ECT
• Current or recent (past one year) Major Depressive Disorder, Bipolar Disorder
• Current or recent (within past 12 months) alcohol or substance abuse or dependence. Recent use (past month) of recreational drugs.
• Dementia Rating Scale (DRS) score less than 135. Medical History Interview
• Neurological Disorders Dementia Rating Scale

Sponsors & Collaborators

• New York State Psychiatric Institute: lead

Study Sites (1)

Columbia University Medical Center

New York, New York, 10032, United States

Location

Related Publications (1)

• Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5638-43. doi: 10.1073/pnas.0611721104. Epub 2007 Mar 20.

  PMID: 17374720 RESULT

MeSH Terms

Conditions

Motor Activity

Interventions

Waiting Lists

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Appointments and Schedules; Organization and Administration; Health Services Administration

Study Officials

• Richard P Sloan, PhD

  Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Scientist

Study Record Dates

• First Submitted: July 28, 2010
• First Posted: April 6, 2011
• Study Start: June 1, 2011
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: March 26, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will share

Locations

US (1)