Frequency and Origin of Dysnatremias in the Emergency Department

NCT01326429 | Withdrawn

• 1 other identifier: KEK 019/11
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Hypo- and hypernatremia are the most frequent electrolyte disorders found in hospitalized patients. The increasing use of diuretics and other medications influencing the water and sodium homeostasis potentially lead to a rise in the prevalence of the electrolyte disorders. Only little data is available on the frequency and the mechanisms leading to hypo-/hypernatremia. Thus, the investigators aim to A.) determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital and B.) explore the mechanisms leading to the development of dysnatremias by detailed clinical and laboratory examinations.

Conditions

Hyponatremia; Hypernatremia

Keywords

Sodium; Hyponatremia; Hypernatremia; Emergency department

Outcome Measures

Primary Outcomes (1)

• Frequency of hypo- and hypernatremia in the emergency department

  The investigators aim to determine the frequency of hypo- and hypernatremia in the emergency department of a large tertiary university hospital.

  approx. 6 months

Secondary Outcomes (1)

• Origin of hypo- and hypernatremia in the emergency department

  approx. 6 months

Study Arms (2)

Hypernatremia

Patients admitted to the emergency department with a serum sodium exceeding 145 mmol/L.

Hyponatremia

Patients admitted to the emergency room with a serum sodium below 135 mmol/L.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients admitted to the emergency department of a large tertiary university hospital with a serum sodium below 135 mmol/L (hyponatremia) or exceeding 145 mmol/L.

You may qualify if:

• Serum sodium below 135 mmol/L (i.e. hyponatremia); serum sodium exceeding 145 mmol/L (hypernatremia)

You may not qualify if:

• Patients below age 18 years; patients declining study participation.

Sponsors & Collaborators

• Insel Gruppe AG, University Hospital Bern: lead
• Steering committee of the NCCR: collaborator

Related Links

• Institution homepage

Biospecimen

Retention: SAMPLES WITH DNA

whole blood

MeSH Terms

Conditions

Hyponatremia; Hypernatremia; Emergencies

Condition Hierarchy (Ancestors)

Water-Electrolyte Imbalance; Metabolic Diseases; Nutritional and Metabolic Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Gregor Lindner, M.D.

  Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern

  PRINCIPAL INVESTIGATOR

• Felix J Frey, M.D.

  Dept. of Nephrology and Hypertension, Inselspital Bern, University of Bern

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: March 29, 2011
• First Posted: March 30, 2011
• Study Start: October 1, 2011
• Primary Completion: March 1, 2013
• Study Completion: March 1, 2013
• Last Updated: July 23, 2015

Record last verified: 2015-07