Effects of Joint Effusion on Quadriceps Muscle
1 other identifier
interventional
40
1 country
1
Brief Summary
The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable knee-osteoarthritis
Started Jun 2009
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2010
CompletedFirst Submitted
Initial submission to the registry
March 14, 2011
CompletedFirst Posted
Study publicly available on registry
March 15, 2011
CompletedMarch 15, 2011
January 1, 2010
7 months
March 14, 2011
March 14, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
the peak torque of the knee extensors
to evaluate the effect of effusion on the peak torque of the knee extensors
within 5 minutes after intervention
Secondary Outcomes (1)
the root mean square values of the vastus medialis and vastus lateralis muscles
within 5 minutes after intervention
Study Arms (2)
normal saline injection
ACTIVE COMPARATOR20 cc normal saline injection into the knee joint
sham injection
SHAM COMPARATORknee injection without saline
Interventions
20 cc normal saline injection into knee joint
Eligibility Criteria
You may qualify if:
- years old or older with knee osteoarthritis
- knee pain without joint effusion confirmed by ultrasonography
You may not qualify if:
- the presence of knee joint effusion determined using US
- a history of knee injury or surgery
- a history of knee injection within 3 months
- a history of inflammatory arthritis
- taking anticoagulants
- balance or gait disturbance
- diabetes mellitus
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Seoul, Seoul, 137-701, South Korea
Related Publications (3)
Fahrer H, Rentsch HU, Gerber NJ, Beyeler C, Hess CW, Grunig B. Knee effusion and reflex inhibition of the quadriceps. A bar to effective retraining. J Bone Joint Surg Br. 1988 Aug;70(4):635-8. doi: 10.1302/0301-620X.70B4.3403614.
PMID: 3403614BACKGROUNDJones DW, Jones DA, Newham DJ. Chronic knee effusion and aspiration: the effect on quadriceps inhibition. Br J Rheumatol. 1987 Oct;26(5):370-4. doi: 10.1093/rheumatology/26.5.370.
PMID: 3664162BACKGROUNDRice D, McNair PJ, Dalbeth N. Effects of cryotherapy on arthrogenic muscle inhibition using an experimental model of knee swelling. Arthritis Rheum. 2009 Jan 15;61(1):78-83. doi: 10.1002/art.24168.
PMID: 19116960BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Jongin Lee, M.D
Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
March 14, 2011
First Posted
March 15, 2011
Study Start
June 1, 2009
Primary Completion
January 1, 2010
Study Completion
June 1, 2010
Last Updated
March 15, 2011
Record last verified: 2010-01