NCT01311193

Brief Summary

Individuals with borderline personality disorder (BPD) frequently suffer from emotional instability, daytime fatigue and sleep disturbances. The investigators examined circadian rhythms, sleep and well-being in women with BPD under their habitual life conditions with and without light treatment. Treated women diagnosed with BPD were investigated during 3 weeks without and 3 weeks with morning LT. Rest-activity cycles were continuously measured using wrist actigraphy, together with proximal skin temperature. Saliva samples were collected weekly to determine the diurnal melatonin rhythm. A range of self-ratings and questionnaires were used to assess depression and clinical state throughout the 6-week protocol. Ten matched healthy women followed the same 6-week protocol without light treatment.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 3, 2011

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 9, 2011

Completed
Last Updated

March 9, 2011

Status Verified

March 1, 2011

First QC Date

March 3, 2011

Last Update Submit

March 7, 2011

Conditions

Borderline Personality DisorderSleep DisturbancesDepression

Keywords

Circadian rhythmsSleep-wake cyclesMelatoninBorderline Personality DisorderLight therapy

Study Arms (1)

light therapy

EXPERIMENTAL

Morning bright light treatment (at 8000 lux for 40min, daily during 3 weeks)

Other: light therapy

Interventions

light therapyOTHER

early morning exposures to bright light, 8000lux for 40min, daily during 3 weeks

light therapy

Eligibility Criteria

Age20 Years - 45 Years
Sexfemale
Age GroupsAdult (18-64)

You may qualify if:

  • Borderline Personality Disorder (DSM IV-criteria)
  • German-speaking
  • normal ocular function

You may not qualify if:

  • lack of compliance

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre for Chronobiology, Psychiatric Hospital, University of Basel

Basel, Canton of Basel-City, 4012, Switzerland

Location

Related Links

MeSH Terms

Conditions

Borderline Personality DisorderParasomniasDepression

Interventions

Phototherapy

Condition Hierarchy (Ancestors)

Personality DisordersMental DisordersSleep Wake DisordersNervous System DiseasesBehavioral SymptomsBehavior

Intervention Hierarchy (Ancestors)

Therapeutics

Study Officials

  • Christian Cajochen, PhD

    Centre for Chronobiology, Psychiatric Hospital, University of Basel

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Sponsor Type
OTHER

Study Record Dates

First Submitted

March 3, 2011

First Posted

March 9, 2011

Last Updated

March 9, 2011

Record last verified: 2011-03

Locations

CH(1)