Zinc Supplementation in Type 2 Diabetics
Does Zinc Supplementation Reduce the Extent of Oxidative Stress Damage in Diabetics? A Randomised Placebo-controlled Study.
1 other identifier
interventional
40
0 countries
N/A
Brief Summary
Zinc supplementation reduces the extent of oxidative damage and improves vascular indices in type 2 diabetics
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_2
Started Jan 2009
Shorter than P25 for phase_2
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2010
CompletedFirst Submitted
Initial submission to the registry
March 2, 2011
CompletedFirst Posted
Study publicly available on registry
March 7, 2011
CompletedMarch 7, 2011
March 1, 2011
1 year
March 2, 2011
March 3, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Markers of oxidative damage
Isoprostanes, HETEs, cholesterol oxidation products, neuroprostanes, allantoin
Three months
Secondary Outcomes (1)
Vascular indices
Three months
Study Arms (2)
Placebo
PLACEBO COMPARATORZinc supplement
EXPERIMENTALInterventions
Zinc gluconate (GNC, USA), 100 mg twice daily
Eligibility Criteria
You may qualify if:
- Subjects aged 21 years and above Subjects with type 2 diabetes mellitus
You may not qualify if:
- Those who consumed over-the counter or prescription drugs, vitamin/mineral supplements or traditional Chinese remedies Those who suffered acute infection less than 30-days prior to the start of the study Those who had been diagnosed with active neuropsychiatric disease or hematological diseases Those who had hemoglobin less than 10g/dL Those who had previous use of narcotic drugs or regular alcohol intake in excess of 14 units per week.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Seet RC, Lee CY, Lim EC, Quek AM, Huang H, Huang SH, Looi WF, Long LH, Halliwell B. Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels. Atherosclerosis. 2011 Nov;219(1):231-9. doi: 10.1016/j.atherosclerosis.2011.07.097. Epub 2011 Jul 26.
PMID: 21840002DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Raymond CS Seet, MBBS
National University Hospital, Singapore
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
March 2, 2011
First Posted
March 7, 2011
Study Start
January 1, 2009
Primary Completion
January 1, 2010
Study Completion
March 1, 2010
Last Updated
March 7, 2011
Record last verified: 2011-03