Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery
TRIMRIPC
Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function
1 other identifier
interventional
60
1 country
1
Brief Summary
The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2011
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2011
CompletedFirst Submitted
Initial submission to the registry
February 2, 2011
CompletedFirst Posted
Study publicly available on registry
March 3, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2013
CompletedAugust 20, 2015
August 1, 2015
2.3 years
February 2, 2011
August 19, 2015
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Mitochondrial respiration
Oxygraph (Strathkelvin)
1 hour
Study Arms (3)
ExerciseTr
EXPERIMENTALRemote ischemic preconditioning group
EXPERIMENTALControl patient group
NO INTERVENTIONInterventions
remote ischemic preconditioning
Eligibility Criteria
You may qualify if:
- Patients undergoing coronary heart surgery and heart transplantation
You may not qualify if:
- myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin \> 140)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Norwegian University of Science and Technologylead
- St. Olavs Hospitalcollaborator
Study Sites (1)
Norwegian University of Science and Technology, Medical Faculty
Trondheim, Sør-Trondelag, 7489, Norway
Related Publications (2)
Slagsvold KH, Moreira JB, Rognmo O, Hoydal M, Bye A, Wisloff U, Wahba A. Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: a randomized trial. Int J Cardiol. 2014 Dec 15;177(2):409-17. doi: 10.1016/j.ijcard.2014.09.206. Epub 2014 Oct 14.
PMID: 25456576RESULTSlagsvold KH, Rognmo O, Hoydal M, Wisloff U, Wahba A. Remote ischemic preconditioning preserves mitochondrial function and influences myocardial microRNA expression in atrial myocardium during coronary bypass surgery. Circ Res. 2014 Feb 28;114(5):851-9. doi: 10.1161/CIRCRESAHA.114.302751. Epub 2013 Dec 26.
PMID: 24371264DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Katrine Hordnes, MD
National Taiwan Normal University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 2, 2011
First Posted
March 3, 2011
Study Start
January 1, 2011
Primary Completion
May 1, 2013
Study Completion
July 1, 2013
Last Updated
August 20, 2015
Record last verified: 2015-08