NCT01304576

Brief Summary

The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
34

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Sep 2010

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 23, 2010

Completed
9 days until next milestone

Study Start

First participant enrolled

September 1, 2010

Completed
6 months until next milestone

First Posted

Study publicly available on registry

February 25, 2011

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2013

Completed
Last Updated

September 3, 2014

Status Verified

September 1, 2014

Enrollment Period

3.3 years

First QC Date

August 23, 2010

Last Update Submit

September 1, 2014

Conditions

Cerebrovascular DisordersBrain Lesions

Keywords

strokeparietal lesions

Outcome Measures

Primary Outcomes (1)

  • orientation agnosia evaluation

    orientation agnosia test

    1 week to 6 months (average)

Secondary Outcomes (1)

  • associated clinical symptoms especially apraxia

    1 week to 6 months (average)

Study Arms (2)

patient with right parietal lesions

EXPERIMENTAL
Behavioral: Neuropsychological testingOther: MRI

patient with left parietal lesions

ACTIVE COMPARATOR
Behavioral: Neuropsychological testingOther: MRI

Interventions

Neuropsychological testingBEHAVIORAL

Experimental test about orientation agnosia and standard neuropsychological tests.

patient with left parietal lesionspatient with right parietal lesions
MRIOTHER

Cerebral MRI

patient with left parietal lesionspatient with right parietal lesions

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • age between 18 and 80 years
  • french language
  • right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion
  • informed consent

You may not qualify if:

  • previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years
  • previous psychiatric history except depression without hospitalization \> one week or anxiety with maximum one anxiolytic treatment
  • drug or alcohol abuse
  • severe cranial traumatism
  • other severe chronic pathology
  • psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month
  • visual impairment
  • motor or sensory deficit sufficient to render impossible neuropsychological tests
  • patient without judicial or administrative liberty
  • measure of legal protection or no capable to express their consent
  • pregnancy or breastfeeding

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Rouen - Hôpitaux de Rouen

Rouen, Haute-Normandie, 76031, France

Location

Related Publications (1)

  • Carlier J, Le Goff F, Pouliquen D, Bliaux E, Bioux S, Gerardin E, Cruypeninck Y, Segobin S, Savoure A, Martinaud O. Evaluation of the cognitive outcome after out-of-hospital cardiac arrest: The role of thalamus. Eur J Neurosci. 2023 Jun;57(11):1892-1912. doi: 10.1111/ejn.15978. Epub 2023 May 8.

    PMID: 37066486DERIVED

MeSH Terms

Conditions

Cerebrovascular DisordersStroke

Interventions

Neuropsychological Tests

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Psychological TestsBehavioral Disciplines and Activities

Study Officials

  • Olivier MARTINAUD, Doctor

    Service de neurologie et centre mémoire de ressources et recherche

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 23, 2010

First Posted

February 25, 2011

Study Start

September 1, 2010

Primary Completion

December 1, 2013

Study Completion

December 1, 2013

Last Updated

September 3, 2014

Record last verified: 2014-09

Locations

FR(1)