Effect of Verb Network Strengthening Treatment (VNeST) on Lexical Retrieval in Aphasia

NCT01300624 | Completed Phase 2 Results

• 1 other identifier: C7695-R
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the effect of Verb Network Strengthening Treatment (VNeST) on the ability to produce sentences and connected speech in persons with aphasia.

Conditions

Aphasia

Keywords

Aphasia; therapy; treatment; verbs; sentences

Outcome Measures

Primary Outcomes (3)

• Trained Sentence Probe

  Picture description task that include trained words.

  pre-treatment, post-treatment and 3-months post-treatment (maintenance)

• Untrained Sentence Probes

  Picture description with sentences containing untrained words.

  pre-treatment, post-treatment and 3-months post-treatment (maintenance)

• Complete Utterances in Discourse

  Sentence in discourse that were relevant to topic and syntactically correct

  pre-treatment, post-treatment and 3-months post-treatment (maintenance)

Secondary Outcomes (4)

• Noun Naming

  pre-treatment and post-treatment

• Verb Naming

  pre-treatment and post-treatment

• Western Aphasia Battery

  pre-treatment and post-treatment

• Communicative Effectiveness Ratings

  pre-treatment, post-treatment and 3-months post-treatment (maintenance)

Study Arms (1)

Verb Network Strengthening Treatment

EXPERIMENTAL

Verb Network Strengthening Treatment (VNeST) tasks involve the retrieval of nouns related to a target verb. For example, for the verb measure, participants would come up with people who measure and what they measure (e.g., carpenter/lumber, chef/sugar). They would then answer questions related to why, where, and when these things might occur (e.g., for carpenter/measure, they might say to get the right length of board, (why) at a construction site, (where) and when building a house (where). Cues and assistance are provided to the participants when they are unable to complete any given task. As the participants improve, cues are reduced.

Behavioral: Verb Network Strengthening Treatment

Interventions

Verb Network Strengthening Treatment BEHAVIORAL

Treatment to improve word retrieval in sentences and discourse for persons with aphasia due to stroke.

Also known as: aphasia treatment, anomia, sentence production, discourse

Verb Network Strengthening Treatment

Eligibility Criteria

• Age: 18 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Veterans with a diagnosis of aphasia
• primary language is English
• aphasia due to stroke

You may not qualify if:

• Functionally bilingual

Sponsors & Collaborators

• US Department of Veterans Affairs: lead

Study Sites (1)

North Florida/South Georgia Veterans Health System

Gainesville, Florida, 32608, United States

Location

MeSH Terms

Conditions

Aphasia

Condition Hierarchy (Ancestors)

Speech Disorders; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Lisa Edmonds, PhD
• Organization: Brain Rehabilitation Research Center, Malcom Randall VA, Gainesville, FL

lisa.annamarie.edmonds@gmail.com

352.262.4465

Study Officials

• Lisa A. Edmonds, PhD

  North Florida/South Georgia Veterans Health System

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 21, 2011
• First Posted: February 21, 2011
• Study Start: March 1, 2011
• Primary Completion: December 1, 2013
• Study Completion: July 1, 2014
• Last Updated: June 9, 2015
• Results First Posted: June 9, 2015

Record last verified: 2015-06

Locations

US (1)